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The role of CCAAT/enhancer binding protein beta2 in mammary epithelial cells
(2010-08-25)
C/EBPbeta is essential for mammary gland growth and development and has been associated with poor prognosis in breast cancer. Overexpression of C/EBPbeta2 in MCF10A cells, a model of normal mammary epithelial cells, results ...
Molecular mechanisms of Gli2 regulation in osteolytic bone disease
(2011-08-30)
Breast cancer frequently metastasizes to the skeleton with severe consequence to patient quality of life. Patients who develop bone metastases suffer from severe bone pain and increased risk of developing hypercalcemia ...
Imaging of Osteolytic Breast Cancer Metastases with Computed Tomography, Positron Emission Tomography and Single Photon Emission Computed Tomography
(2010-04-12)
Imaging protocols for detection of breast cancer metastases to bone in clinical imaging have long been standardized, but to date small animal imaging still uses a variety of imaging modalities and protocols. Although imaging ...
Biomolecular Signatures of Disease via Ion Mobility and Mass Spectrometry Techniques
(2014-04-01)
Ion mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
Learning the State of Patient Care and Opportunities for Improvement from Electronic Health Record Data with Applications in Breast Cancer Patients
(2017-04-17)
Patient care is complex and imperfect. Understanding and improving patient care requires clinical datasets and scientific methodology. We designed a set of methods to characterize the state of patient care and identify ...
The role of mTORC2 in mammary morphogenesis and HER2-mediated tumorigenesis
(2015-07-09)
CANCER BIOLOGY
The role of mTORC2 in mammary morphogenesis
and HER2-mediated tumorigenesis
Meghan Melinda Morrison
Dissertation under the direction of Professor Rebecca Cook
The phosphatidyl inositol-3-kinase (PI3K)/Akt ...
Assessing Treatment Response of HER2+ Breast Cancer Xenografts with PET and MRI
(2013-07-29)
With the development of anti-cancer therapies that specifically target the tumor and its microenvironment, the current radiographic analysis of treatment response that uses one-dimensional changes in tumor size may not be ...
Regulation of CXC Chemokine Receptor Function Through Intracellular Trafficking and Novel Receptor-Interacting Proteins
(2008-03-06)
Chemokines are a family of small chemotactic cytokines that bind seven transmembrane G protein-coupled receptors. Roles for CXC chemokines and the receptors CXCR2 and CXCR4 in inflammation-mediated tumorigenesis, angiogenesis, ...
Combining laser capture microdissection and MALDI mass spectrometry for tissue protein profiling: methodology development and clinical applications
(2005-03-09)
The combination of laser capture microdissection (LCM) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) for protein profiling from specific cells of interest within heterogeneous tissue is ...
Development of Optical Imaging of Metabolism for Monitoring and Predicting Drug Efficacy
(2015-03-11)
A clinical need exists for improved methods to identify cancer patients with tumors prone to drug resistance, and prescribe effective alternative therapies. Cellular metabolism is a powerful marker of tumor response to ...