RSS 1.0Electronic Theses and Dissertations
This collection holds electronic theses and dissertations of masters and doctoral students submitted to the Graduate School.
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(2020-11-20)Faithful duplication of DNA lies at the center of DNA replication, defects in which can lead to cancer and other diseases of genomic instability. Generating copies of the two stands of the DNA duplex begins with synthesis ...
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(2020-11-19)To extend Moore’s law, transformative changes have been implemented to maintain device scaling. In this dissertation, I focus on the state-of-the-art technologies for future logic and RF applications. The semiconductor ...
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(2020-11-18)For over 30 years, an HIV-1 vaccine has remained elusive due to the high mutability and tremendous levels of genetic diversity exhibited by the virus. Current research efforts have focused on understanding B cell-encoded ...
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(2020-11-18)SERINC5 is a 10-12 transmembrane domain cellular protein that is incorporated into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV-1 susceptibility to SERINC5 is determined by ...
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(2020-11-17)Volume Regulated Anion Channels (VRACs) encoded by the LRRC8 gene family play critical roles in myriad cellular processes and might represent druggable targets. The dearth of pharmacological compounds available for studying ...
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(2020-11-17)This work provides a high-speed flash-analog-to-digital converter with an increased resistance to ionizing radiation, specialized for use in sub-50 nm Silicon-On-Insulator technology nodes. When applying Radiation Hardened ...
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(2020-11-18)It has been known for some time that attention is often guided by what other people look at and speak about, which can in turn invoke inferences about the beliefs, desires, and goals that drive their forms of reference, a ...
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(2020-11-18)The American Cancer Society estimates that over 250,000 new cases of invasive breast cancer are diagnosed annually in the United States. Subtyping breast cancer and the identification of targeted therapies have greatly ...
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(2020-11-16)Malignant migrating partial seizures of infancy is a rare, devastating form of epilepsy most commonly associated with gain-of-function mutations in the potassium channel, Slack. Not only is this condition almost completely ...
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(2020-11-16)Medication adherence is a complex set of time-varying behaviors—filling, ingesting, and refilling medication at the right time and in the right manner—necessary to effective pharmacotherapy. Proper methods of quantifying ...
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(2020-11-16)The spinal cord is a narrow, cylindrical structure responsible for rapidly transmitting electrical signals throughout the nervous system and is the primary sensorimotor pathway for the human body. Therefore, damage to the ...
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(2020-11-16)Despite growing calls for teaching that is justice-oriented, such as culturally sustaining pedagogy, social justice mathematics, and anti-racist teaching, mechanisms and theories for supporting STEM teachers’ learning of ...
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(2020-11-12)Cyber-physical systems -- physical processes that are controlled by computational frameworks across networks -- have seen a large scale digitalization and democratization due to the improvements in edge computing, the ...
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(2020-11-20)This study focuses on social change, resource management, cooperation, and fairness among Tzotzil-Maya communities in the highlands of Chiapas, southern Mexico. Maya groups in Chiapas have undergone drastic changes over ...
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(2020-11-18)In the big data era, person-specific data are being collected in an unprecedented manner. Given the potential wealth of insights in personal data, many organizations aim to share data while protecting privacy by sharing ...
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(2020-11-18)A fundamental question in decision-making is how instructions can be used to influence behavior. Nowhere is this question more important than in the legal system, in which the fate and lives of individuals are in the ...
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(2020-11-06)Electronic health records (EHRs) provide unprecedented amounts of data, facilitating entirely new kinds of observational research studies. One valuable and challenging area of research enabled by these databases is ...
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(2020-11-19)Helicobacter pylori colonizes the stomach in about half of the world’s population. Gastric colonization with H. pylori strains containing the cag pathogenicity island (cag PAI) is a risk factor for gastric adenocarcinoma ...
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(2020-12-06)The oncoprotein transcription factor MYC is a major driver of malignancy and a highly-validated target for development of anti-cancer therapies. It has, however, proven challenging to inhibit MYC directly. Novel strategies ...
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Early Events in RNA Virus Infection: Profiling the Pre-Replicated Interactome of Chikungunya Virus (2020-11-05)The race between RNA virus replication and the host innate immune response begins immediately after viral infection. While awaiting transcriptional upregulation of interferons and antiviral genes, cells must rely on mRNAs ...