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The Vanderbilt University Institutional Repository (VUIR) provides open access to faculty scholarly work, preserves historically significant digital materials, and supports the university in scholarly communications and the dissemination of knowledge. Faculty, researchers, staff and students are invited to contribute digital materials to ensure long term preservation and access. Learn more....
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(2020-11-20)Faithful duplication of DNA lies at the center of DNA replication, defects in which can lead to cancer and other diseases of genomic instability. Generating copies of the two stands of the DNA duplex begins with synthesis ...
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(2020-11-19)To extend Moore’s law, transformative changes have been implemented to maintain device scaling. In this dissertation, I focus on the state-of-the-art technologies for future logic and RF applications. The semiconductor ...
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(2020-11-18)For over 30 years, an HIV-1 vaccine has remained elusive due to the high mutability and tremendous levels of genetic diversity exhibited by the virus. Current research efforts have focused on understanding B cell-encoded ...
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(2020-11-18)SERINC5 is a 10-12 transmembrane domain cellular protein that is incorporated into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV-1 susceptibility to SERINC5 is determined by ...
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(2020-11-17)Volume Regulated Anion Channels (VRACs) encoded by the LRRC8 gene family play critical roles in myriad cellular processes and might represent druggable targets. The dearth of pharmacological compounds available for studying ...