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The epithelial IL4 receptor signaling axis mediates enhanced breast and colon tumor growth and metastasis
(2016-03-17)
Epithelial cancers of the lung, colon, breast, and pancreas comprise the top four most deadly cancers. Progress has been made in treating primary epithelial tumors, however metastatic tumors remain largely incurable and ...
Molecular mechanisms of Gli2 regulation in osteolytic bone disease
(2011-08-30)
Breast cancer frequently metastasizes to the skeleton with severe consequence to patient quality of life. Patients who develop bone metastases suffer from severe bone pain and increased risk of developing hypercalcemia ...
LIFR-Mediated Tumor Dormancy and Mechanisms of Breast Cancer Dissemination to Bone
(2019-03-29)
Despite the high prevalence of breast cancer metastasis to bone, there are currently no therapeutic options to cure metastatic disease. This deficit is in part due to the lack in vivo models that recapitulate prolonged ...
The role of p120 catenin in mammary development and breast cancer
(2012-04-04)
Cadherins and catenins are important regulators of tissue homeostasis and cancer. Here, we report critical roles for p120 catenin (p120) in mammary development and breast cancer. In the untransformed gland, p120 ablation ...
Roles of Fibroblast MMP2 in Breast to Lung Metastasis
(2015-03-18)
CANCER BIOLOGY
Roles of Fibroblast MMP2 in Breast to Lung Metastasis
Andreia L. Bates
Dissertation under the direction of Barbara Fingleton, PhD
Breast cancer five-year survival rates decrease from 99% for patients ...