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Visualization of nuclear targeting of breast cancer cell lines. [and] Quantification and detection of matrilysin produced by five cancer cell lines
(2006-12-19)
The collection of visual evidence of M13 bacteriophage displaying a nuclear localization heptapeptide localizing to the nuclei of breast cancer cells is described in this thesis. The bacteriophages displaying the heptapeptide ...
Mechanisms of Cisplatin Resistance in Triple Negative Breast Cancer
(2014-11-26)
Genomic instability and deregulated proliferation are hallmarks of human tumors. Cytotoxic chemotherapeutics, including cisplatin, have been used for over forty years to combat cancers that have deregulated proliferation ...
Optical spectroscopy for the evaluation of surgical margin status following breast cancer resection
(2009-12-23)
The presence of tumor within 1-2 millimeters of the surgical margin following partial mastectomies is strongly correlated with the risk of local breast tumor recurrence; thus, there is a need to develop a non-invasive, ...
Roles of the alpha2beta1 Integrin in Cancer Progression and Metastasis
(2011-12-12)
In this dissertation, I examined the function of the alpha2beta1 integrin in epithelial tumor cells as well as in the tumor microenvironment. The alpha2beta1 integrin is a surface heterodimeric receptor found on epithelial, ...
Targeting K-Ras, Pak-1, And Mcl-1 for the Treatment of Cancer
(2015-11-24)
Malignant cancers are the second leading cause of death in the United States, with a projected 1.6 million new diagnoses per year and almost 600,000 deaths. Our understanding of the molecular pathways causing tumor initiation, ...
TGFbeta signaling enhances wound healing inflammation in post-partum breast cancer.
(2014-12-02)
Breast cancer is the leading cancer diagnosis in pre-menopausal women in the U.S. Of these breast cancers, 25% are diagnosed 2-5 years post-partum. Unfortunately, post-partum breast cancers (ppBCs) are highly metastatic. ...
Focused Ultrasound for the Generation of Cancer Immunotherapy
(2016-11-23)
Cancer immunotherapies, which seek to arm the patient’s own immune system for personalized therapy, are a promising option for effective elimination of tumors. Focused ultrasound (FUS) is one propitious method for generating anti-tumor immunotherapy, advantageous in its capacity to deliver non-ionizing, non-invasive, tumor-localized treatment; this involves the transdermal deposition of sonic energy at a focal point in the tumor, which induces acute inflammation capable of activating an anti-tumor immune response. Here, we characterize, in vivo, the early (48 hours) adaptive anti-tumor immune responses induced by FUS treatment of tumors. Compared to untreated tumors, tumors treated with mechanical FUS (mFUS) demonstrated increased NF-κB activation in local and distant tumors. Additionally, a “responder” subset of mFUS-treated mice was identified and mFUS-treated tumors exhibited an increased percent of CD4+ T cells and an increased CD4+/CD8+ T cell ratio, as compared to untreated tumors. Immunohistochemical analysis of CD4+ T cells revealed a higher presence of immunostimulatory phenotypes in mFUS-treated tumors compared to untreated tumors. Taken together, these results suggested a FUS-induced shift towards anti-tumor immune activity....
Regulation of C/EBPbeta1 in transformed mammary epithelial cells and the role of C/EBPbeta1 in oncogene-induced senescence
(2010-12-10)
Overexpression of activated oncogenes such as Ras(V12) in primary cells induces senescence rather than transformation, thus suppressing tumorigenesis. C/EBPbeta is required for Ras(V12)-induced senescence in mouse embryonic ...
Targeting Gli-Mediated Transcription in Bone Metastasis: An Emerging Therapeutic Approach for Patients with Tumor-Induced Bone Disease
(2021-03-29)
Bone is a common site of metastasis for advanced breast, prostate, and lung cancer. Most patients with skeletal metastases develop tumor-induced bone disease (TIBD), which is characterized by a vicious cycle of tumor growth ...
Regulation of CXC Chemokine Receptor Function Through Intracellular Trafficking and Novel Receptor-Interacting Proteins
(2008-03-06)
Chemokines are a family of small chemotactic cytokines that bind seven transmembrane G protein-coupled receptors. Roles for CXC chemokines and the receptors CXCR2 and CXCR4 in inflammation-mediated tumorigenesis, angiogenesis, ...