• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Focused Ultrasound for the Generation of Cancer Immunotherapy

    Dockery, Mary Diana
    : https://etd.library.vanderbilt.edu/etd-11212016-145818
    http://hdl.handle.net/1803/14703
    : 2016-11-23

    Abstract

    Cancer immunotherapies, which seek to arm the patient’s own immune system for personalized therapy, are a promising option for effective elimination of tumors. Focused ultrasound (FUS) is one propitious method for generating anti-tumor immunotherapy, advantageous in its capacity to deliver non-ionizing, non-invasive, tumor-localized treatment; this involves the transdermal deposition of sonic energy at a focal point in the tumor, which induces acute inflammation capable of activating an anti-tumor immune response. Here, we characterize, <em>in vivo</em>, the early (48 hours) adaptive anti-tumor immune responses induced by FUS treatment of tumors. Compared to untreated tumors, tumors treated with mechanical FUS (mFUS) demonstrated increased NF-κB activation in local and distant tumors. Additionally, a “responder” subset of mFUS-treated mice was identified and mFUS-treated tumors exhibited an increased percent of CD4+ T cells and an increased CD4+/CD8+ T cell ratio, as compared to untreated tumors. Immunohistochemical analysis of CD4+ T cells revealed a higher presence of immunostimulatory phenotypes in mFUS-treated tumors compared to untreated tumors. Taken together, these results suggested a FUS-induced shift towards anti-tumor immune activity.
    Show full item record

    Files in this item

    Icon
    Name:
    Dockery_Final2.pdf
    Size:
    2.279Mb
    Format:
    PDF
    View/Open

    This item appears in the following collection(s):

    • Electronic Theses and Dissertations

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy