Browsing Electronic Theses and Dissertations by Subject "macrophage"
Now showing items 1-10 of 10
-
(2018-07-22)Department: Molecular Physiology and BiophysicsThe phagocytic nature and oxidative resiliency of macrophages not only allows them to function as innate immune cells but also to respond to specific tissue needs, such as iron homeostasis. MFehi ATMs are a subtype of ...
-
(2022-05-11)Department: Molecular Pathology & ImmunologyMetabolism determines cell function and fate across tissues and disease states. Proliferative cells upregulate anabolic metabolism to support cell growth, division, and other activities. Glucose and glutamine are critical ...
-
(2017-08-29)Department: Microbiology and ImmunologyThe growing incidence of nosocomial infection with antibiotic-resistant organisms requires novel approaches to decrease their incidence and severity. Predicting the infection risk of an individual host and restoring host ...
-
(2015-07-16)Department: Molecular Physiology and BiophysicsReduced pancreatic β cell mass is a hallmark of diabetes, which makes the ability to increase or restore β cell mass a major therapeutic goal. While testing the hypothesis that increased endothelial cell signaling would ...
-
(2014-12-31)Department: Cell and Developmental BiologyBronchopulmonary dysplasia is a life-threatening lung disease affecting low birth weight preterm infants. While the occurrence of BPD is correlated with chorioamnionitis, the origination and pathway of fetal lung inflammation ...
-
(2019-01-08)Department: Microbiology and ImmunologyStreptococcus agalactiae, also known as Group B Streptococcus (GBS) is a common perinatal pathogen, and GBS vaginal colonization is a major risk factor for infection-related adverse pregnancy outcomes including preterm ...
-
(2013-12-04)Department: Biomedical EngineeringBiodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by hydrolysis. PLGA hydrolysis generates acidic byproducts that trigger an ...
-
(2013-04-11)Department: Molecular Physiology and BiophysicsObesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
-
(2009-07-28)Department: PathologyMacrophage foam cells are prominent in atherosclerotic lesions. In late stage disease, much of the cholesterol accumulation within foam cells is found in large, swollen, lysosomes. Tissue culture models using human macrophages ...
-
(2015-06-05)Department: Cell and Developmental BiologyRetinoic acid (RA) has been used therapeutically to reduce injury and fibrosis in models of acute kidney injury (AKI), but little is known about whether and how this pathway is normally regulated, and what role it plays ...