Browsing Electronic Theses and Dissertations by Department "Cell and Developmental Biology"
Now showing items 81-100 of 179
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(2017-08-11)Department: Cell and Developmental BiologyIn Schizosaccharomyces pombe cytokinesis requires assembly and constriction of an actomyosin-based contractile ring (CR). Nucleation of F-actin for the CR requires a single essential formin, Cdc12, that localizes to the ...
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(2013-04-17)Department: Cell and Developmental BiologyThe Cdc14 phosphatase family antagonizes Cdk1 phosphorylation and is important for mitotic exit. Dynamic localization is a major means of regulating this phosphatase family, yet how localization changes occur, or how ...
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(2010-03-22)Department: Cell and Developmental BiologyEpithelial cells lining the lumen of the small intestine, called enterocytes, possess an exquisitely ordered array of microvilli collectively referred to as the brush border (BB). Microvilli are actin-rich membrane protrusions ...
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(2017-09-21)Department: Cell and Developmental BiologyTuberous Sclerosis Complex (TSC) is a pediatric disorder of dysregulated growth and differentiation caused by loss of function mutations in either the TSC1 or TSC2 genes, which regulate mTOR kinase activity. TSC causes ...
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(2015-03-25)Department: Cell and Developmental BiologyAs diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
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Modulation of Sonic Hedgehog signaling alters cerebellar development and medulloblastoma formation (2013-12-10)Department: Cell and Developmental BiologyCerebellar development is a complex process involving the tightly regulated proliferation, specification, migration, and connectivity of thousands of neurons and glia. Perturbations in signaling pathways important for these ...
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(2012-08-06)Department: Cell and Developmental BiologyNeural function depends on the creation of synapses between specific neurons. Across species, transcription factor codes regulate the precise connectivity between neurons. In the C. elegans motor circuit, these critical ...
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(2012-07-23)Department: Cell and Developmental BiologyOrganisms across phylogeny have neuronal circuits that control everyday activities. The somatosensory network, for example, is specifically utilized to sense the external environment and is important to properly inform ...
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Myocardial Differentiation is Dependent on Endocardial Signaling During Early Cardiogenesis in vitro (2018-10-23)Department: Cell and Developmental BiologyNearly 1% of all newborns are diagnosed with congenital heart defects (CHDs), which is the leading cause of morbidity and mortality among infants. Thus, it is essential that we continue efforts to expand our knowledge ...
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(2011-12-12)Department: Cell and Developmental BiologyClass I myosins are monomeric actin-binding, ATP hydrolyzing molecular motors that are expressed in a variety of cell types, and function at the membrane-actin interface. Myosin-1d, one of eight vertebrate class I myosins, ...
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(2017-07-13)Department: Cell and Developmental BiologyCytokinesis is the final step in the cell cycle where one cell is physically divided into two. Animal and fungal cells perform cytokinesis with an actin- and myosin-based molecular machine, the contractile ring. A complete ...
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(2014-12-31)Department: Cell and Developmental BiologyBronchopulmonary dysplasia is a life-threatening lung disease affecting low birth weight preterm infants. While the occurrence of BPD is correlated with chorioamnionitis, the origination and pathway of fetal lung inflammation ...
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(2013-09-18)Department: Cell and Developmental BiologyArrested lung development in preterm infants leads to bronchopulmonary dysplasia (BPD). Inflammation and NF-κB activation in the fetal lung inhibit airway morphogenesis and contribute to BPD. The mesenchymal growth factor ...
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Ngn3-expressing progenitor heterogeneity drives endocrine lineage allocation in pancreas development (2015-11-17)Department: Cell and Developmental BiologyDiabetes is a worldwide health issue. In both type I and late stage type II diabetes, significant beta-cell loss causes insulin deficiency and hyperglycemia. Replenishing beta cells is a promising therapy and it requires ...
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(2016-03-30)Department: Cell and Developmental BiologyTwo processes influence the success of mitosis, the process by which eukaryotic cells divide their replicated genome into two new daughter cells. First, the cell must build a bipolar array of microtubules called the mitotic ...
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(2011-03-14)Department: Cell and Developmental BiologyCholangiopathies, or diseases which affect the biliary epithelial cells of the liver, are an important health concern in the United States. Specifically, the diagnosis of a cholangiopathy is the number one indicator of ...
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(2014-12-19)Department: Cell and Developmental BiologyThe Notch signaling pathway is an essential cell-cell signaling pathway that is involved in cell fate decisions and cell differentiation during early metazoan development. In humans, the Notch pathway is misregulated in ...
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(2013-06-10)Department: Cell and Developmental BiologyEpithelial-to-Mesenchymal Transformation (EMT) is an important process in development, and occurs during key steps in both valvular and coronary vessel development. This dissertation uses transcriptional profiling strategies ...
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(2013-12-04)Department: Cell and Developmental BiologyThe genome of a eukaryotic cell tightly packed within the nucleus with a high degree of structural organization. Two mechanisms accounting for nuclear structure and the dynamics of subnucler organization in S. cerevisiae ...
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(2006-11-01)Department: Cell and Developmental BiologyThe microtubule cytoskeleton of most animal oocytes differs from that of somatic cells in that the centrioles are lost during oogenesis. In most animals, female meiotic spindles assemble in the absence of centrosomes; ...