Browsing Electronic Theses and Dissertations by Department "Chemical and Physical Biology"
Now showing items 41-60 of 67
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(2019-05-01)Department: Chemical and Physical BiologyThe human brain is comprised of spatially separable, functionally discrete networks which can be mapped in vivo using multimodal magnetic resonance imaging (MRI). MRI permits interrogation of both the neuroanatomy of healthy ...
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(2015-08-20)Department: Chemical and Physical BiologyThe loss of inhibition of glucagon secretion exacerbates hyperglycemia in types 1 and 2 diabetes. However, the molecular mechanisms that regulate glucagon secretion in unaffected and diabetic states remain relatively ...
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(2016-11-18)Department: Chemical and Physical BiologyThe development, validation, and application of novel methods to quantify glucose metabolism are presented in this thesis. The methodologies use stable isotope tracers, gas chromatography-mass spectrometry, and mathematical ...
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(2011-12-15)Department: Chemical and Physical BiologyAcetycholine is one of the major neurotransmitters that regulate various functions ranging from cognition to motor. It activates muscarinic acetylcholine receptors (mAChRs), which are highly expressed in the brain. mAChRs ...
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(2017-08-02)Department: Chemical and Physical BiologyOne of the basic tenets of biology and biochemistry is that form meets function; this axiom is applicable to all levels of life. Structural data on large classes of proteins, such as membrane proteins (MPs), is largely ...
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(2014-11-25)Department: Chemical and Physical BiologyAcousto-Optical Imaging (AOI) is an emerging hybrid multi-modal imaging technique that combines the high spatial resolution of ultrasound with the versatile molecular sensitivity of optical detection to improve upon the ...
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(2018-03-24)Department: Chemical and Physical BiologyFocused ultrasound (FUS) is a non-invasive technology with a growing body of applications in interventional therapy and preclinical research. FUS uses geometrically focused transducers that transmit convergent acoustic ...
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(2015-03-25)Department: Chemical and Physical BiologyMembrane proteins remain a particular challenge in structural biology. Only approximately 1.5% of reported tertiary structures and around 100 unique polytopic membrane proteins are represented in the Protein Data Bank ...
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(2014-11-24)Department: Chemical and Physical BiologyIntratumor heterogeneity underlies the failure of targeted cancer therapy. The origins of this phenotypic variability derive from the coincident contributions of genetic, non-genetic, and stochastic factors. However, few ...
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(2015-03-24)Department: Chemical and Physical BiologyOncogenic mechanisms in small-cell lung cancer (SCLC) remain poorly understood leaving this tumor with the worst prognosis among all lung cancers. Unlike other cancer types, sequencing genomic approaches have been of limited ...
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(2014-06-12)Department: Chemical and Physical BiologyHuman antibodies are critical for eradication of viral and bacterial infections, while providing the basis for immunological memory. Antibody design using the molecular modeling suite Rosetta is used to answer questions ...
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(2013-12-13)Department: Chemical and Physical BiologyThis thesis has been focused on understanding structure-function relationships of transport proteins and the development of hybrid computational and spectroscopic approaches to understanding protein biology. The widespread ...
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(2011-02-17)Department: Chemical and Physical BiologyAlkylating agents covalently modify DNA bases to generate a chemically diverse set of lesions including cytotoxic N3-methyladenine (3mA) bases and mutagenic 1,N6-ethenoadenine (εA) and N7-methylguanine (7mG). To maintain ...
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(2012-04-21)Department: Chemical and Physical BiologyAdenovirus has been studied for many years for its potential as a gene delivery vector in gene therapy applications. One of the more challenging problems under research is the design of Adenoviral vectors that can be ...
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(2017-08-01)Department: Chemical and Physical BiologyThe long-term goal of this study is to evaluate key changes that occurred as a result of evolution from bacteria to the human respiratory enzyme, Complex II. Complex II has been extensively studied to define its roles in ...
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(2013-07-29)Department: Chemical and Physical BiologyThe metabotropic glutamate receptor subtype 5 (mGlu5), a class C G-protein coupled receptor (GPCR), is involved in cognitive function through diverse signaling pathways that modulate synaptic plasticity. Modulators of mGlu5 ...
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(2014-03-17)Department: Chemical and Physical BiologyPrions are infectious proteins; aberrantly folded proteins with self-propagating structures that induce a biological effect. Prions are implicated in a number of diseases, including the transmissi- ble spongiform ...
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(2017-08-04)Department: Chemical and Physical BiologyC. difficile is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis worldwide. The major virulence factors in CDI (TcdA and TcdB) are members of the Large Clostridial Toxin (LCT) family. Due to the ...
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(2015-11-27)Department: Chemical and Physical BiologyChemical and Physical Biology Structures of the 3,4-Epoxybutene-Derived R- and S-N1-(2-Hydroxy-buten-2-yl) -2' Deoxyinosine DNA Adducts: Regiochemical Control of Glycosidic Torsion Angle Conformation Dennis Kuo Thesis ...
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(2013-04-15)Department: Chemical and Physical BiologyThis project is focused on PET probe development for cancer imaging by targeting a potential cancer biomarker- Translocator Protein (TSPO). In this project, I evaluated 18F-DPA-714, a pyrazolopyrimindine probe, as a TSPO ...