Browsing Electronic Theses and Dissertations by Department "Chemical and Physical Biology"
Now showing items 21-40 of 67
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(2012-10-18)Department: Chemical and Physical BiologyCurrent medical ability to diagnose and treat disease remains limited for many chronic diseases such as cancer, carcinoids, diabetes, and obesity. Basic research promises to advance our understanding of such conditions and ...
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Development of methods for docking and designing small molecules within the Rosetta code framework (2012-10-15)Department: Chemical and Physical BiologyStructure-based drug design is a key challenge for pharmaceutical chemists. By studying the structure of proteins bound to natural substrates, researchers can design small molecules which they predict will bind in a similar ...
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(2015-07-21)Department: Chemical and Physical BiologyThe ability to make rapid predictions of macro-molecular structures will enable researchers to carry out effective protein design, virtual High Throughput Screening (vHTS) and rational drug design studies. Here, we describe ...
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(2014-03-19)Department: Chemical and Physical BiologySimple and rapid methods for detecting RNA biomarkers from patient samples are especially desirable in settings with limited access to laboratory resources and trained personnel. The focus of this dissertation is on the ...
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(2014-12-03)Department: Chemical and Physical BiologyCurrent chemotherapeutic treatments for cancer utilize systemic administration of cytotoxic drugs and produce many side effects in healthy tissues, making optimal treatment of cancer hard to achieve. Tumor targeted ...
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(2014-07-22)Department: Chemical and Physical BiologyThe muscarinic acetylcholine receptors (mAChRs) are a family of G protein-coupled receptors comprised of five subtypes (M1-5) expressed throughout the central nervous system (CNS). These receptors, together with their ...
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(2009-12-14)Department: Chemical and Physical BiologyPositron emission tomography (PET) imaging using the radiotracer 3’-deoxy-3’-[18F]fluorothymidine ([18F]-FLT) has shown potential as a biomarker of proliferation in tumors. [18F]-FLT measures the activity of thymidine ...
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(2018-09-21)Department: Chemical and Physical BiologyAntibodies are a key component of the human immune response to infectious disease. The best anti-viral antibody response is one that is potent and broad, covering a large number of the many diverse viral variants. ...
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(2014-05-29)Department: Chemical and Physical BiologyChlamydiae species are obligate intracellular pathogens that utilize a type three-secretion system (T3SS) to deliver effector proteins and manipulate host cell processes. T3SSs are composed of cytosolic components, a needle ...
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(2014-07-03)Department: Chemical and Physical BiologyProstaglandin glycerol esters (PG-Gs) are produced by the oxygenation of the endocannabinoid, 2-arachidonoylglycerol, by cyclooxygenase 2. Understanding the role that PG-Gs play in a biological setting has been difficult ...
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(2018-07-11)Department: Chemical and Physical BiologyStructure elucidation for large membrane proteins remains a challenging task. As membrane protein structure determination is entering another stage of probing the ensemble of dynamic structures, methods such as NMR, EPR ...
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(2017-09-25)Department: Chemical and Physical BiologyCerebrovascular disease (CVD) encompasses conditions that affect the blood supply to the brain. CVD results in hemodynamic impairment, and when the brain can no longer compensate for decreased oxygen delivery to tissue, ...
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(2012-12-03)Department: Chemical and Physical BiologyiASPP (inhibitory member of the apoptosis stimulating protein of p53 family) is known to inhibit the important tumor suppressors p53 and p73. Indeed, iASPP is over-expressed in several cancer types and is associated with ...
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(2014-05-27)Department: Chemical and Physical BiologyThe ubiquitin-like protein LC3 is a central component of the autophagy pathway where it functions in autophagosome formation and cargo selection. LC3 has an extensive network of interacting proteins, but little is known ...
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(2012-07-23)Department: Chemical and Physical BiologyMembrane protein structures are very difficult to determine by solution NMR since severe line-broadening obstructs the measurement of restraints. To alleviate this problem we describe the measurement of paramagnetic ...
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(2018-07-16)Department: Chemical and Physical BiologyαB-crystallin is a member of the small heat shock protein (sHSP) superfamily. Mutations in αB-crystallin cause autosomal cataracts and cardiomyopathy, but the exact role of αB-crystallin in the lens and heart remains ...
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(2016-04-09)Department: Chemical and Physical BiologyBrown adipose tissue (BAT) known to function in a non-shivering thermogenic capacity, also performs as an endocrine organ, and assists with glucose homeostatsis and insulin sensitivity. Positron emission tomography ...
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(2012-12-04)Department: Chemical and Physical BiologyIn this thesis, the power of synthetic chemistry and colloidal nanotechnology are employed in the advancement of cell therapy and imaging. A new approach to dendritic cell (DC)-based immunotherapy is examined with the use ...
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(2011-07-29)Department: Chemical and Physical BiologyCHEMICAL AND PHYSICAL BIOLOGY NMR STUDIES OF THE RPA DIMER CORE RPA32D/14 ILEANA ALERS RIVERA Thesis under the direction of Professor Walter J. Chazin Replication protein A (RPA) is the primary eukaryotic single-stranded ...
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(2014-03-20)Department: Chemical and Physical BiologyThis Thesis is comprised of four chapters that, respectively: 1) Examine the potential value of studying cellular dynamics and heterogeneity in the context of emerging biological warfare threats; 2) Review both the advantages ...