Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 121-140 of 363
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(2014-08-04)Department: ChemistryMembrane-electrode-assemblies (MEAs) were fabricated with electrospun nanofiber electrodes containing 40% Pt/C, a binder of Nafion and poly(acrylic acid), and a Nafion 212 cation-exchange membrane. MEA performance in a ...
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(2020-01-24)Department: ChemistryTo investigate this dynamic response at the level of individual molecular species, human embryonic kidney (HEK)-293 cells were stably transfected with hemagglutinin (HA)-tagged human muscarinic-1 acetylcholine receptors ...
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(2018-04-11)Department: ChemistryCarboxylic acids are employed throughout nature and synthetic chemistry as reactants as well as catalysts. However, carboxylic acids are underrepresented as nucleophiles in enantioselective organic reactions. This may be ...
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(2015-12-11)Department: ChemistryThe Nutlin class of cis-imidazoline small molecule therapeutics has been shown to inhibit the protein-protein interaction (PPI) between the tumor-suppressor protein p53 and MDM2. The more potent enantiomer of Nutlin-3, ...
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(2018-01-02)Department: ChemistryAs a class of reagents, organocatalysts have served the enabling role for many high-value reactions. Innovations in organocatalysis, along with these new reactions, have improved our access to new developmental therapeutics ...
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(2016-04-21)Department: ChemistryIon mobility-mass spectrometry (IM-MS) is an analytical technique used to separate gas-phase ions based on their structural properties such as size and shape as well as their mass, in the IM and MS dimensions, respectively. ...
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(2017-02-10)Department: ChemistryThe process of photosynthesis has served as a natural solar energy conversion system in autotrophs for billions of years. This complex biological process provides inspiration and key machinery that may be utilized in ...
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(2013-03-01)Department: ChemistryThe most common approaches to treatment of cancer are chemo- and radiation-therapies that cause DNA damage. The efficiency of these treatments is reduced over time because cells up-regulate DNA damage response and repair. ...
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(2022-05-16)Department: ChemistryKnowledge of peptide and protein structure is critical for understanding how they carry out their biological roles. In this dissertation, I describe how two-dimensional infrared (2D IR) spectroscopy coupled with isotope ...
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(2011-12-09)Department: ChemistryThe proteomic response of Staphylococcus aureus bacteria in a biofilm is examined using MALDI Imaging Mass Spectrometry (IMS) and Liquid-Chromatography Tandem Mass Spectrometry (LC-MS/MS). S. aureus biofilms grown in-vitro ...
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(2018-08-27)Department: ChemistryNatural products remain valuable sources for modern drug discovery, yet natural product discovery is hindered by poor production in lab cultivated organisms and/or poor observability from complex microbial extracts. We ...
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(2008-04-03)Department: ChemistryThis research project was directed at improving the performance and expanding the application of backscattering interferometry (BSI). It will be shown that several steps, including the implementation of sample and reference ...
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(2011-11-28)Department: ChemistryAdvances are being made in lighting technology, as incandescent and fluorescent light bulbs become less efficient compared to solid-state lighting devices, especially light-emitting diodes (LEDs). Cadmium selenide (CdSe) ...
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(2011-09-15)Department: ChemistryThis dissertation focuses on two projects that attempt to solve two unique challenges. Biomimetic synthesis inspired by diatoms provides the mechanism for developing functional materials under ambient conditions. The goal ...
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(2014-11-24)Department: ChemistryGold’s resistance to oxidation and exhibition of unique chemical and physical properties enable the development of current sensor and diagnostic platforms. This dissertation elucidates novel sensor platforms for the rapid ...
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(2014-07-29)Department: ChemistryAnalysis of crystal structures of native antibodies bound to the hemagglutinin (HA) surface receptor of influenza have provided pertinent chemical information and metrics of the antibody-antigen interactions at the ...
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(2012-09-28)Department: ChemistryGold-coated magnetic polymer microspheres (AuMPMs) are multi-component particles readily functionalized via gold-thiol chemistry, and can be strategically manipulated by a magnetic field. The research probes the uniformity, ...
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(2017-08-09)Department: ChemistryThe field of nanomedicine capitalizes on the unique chemical and physical properties of nanoscale materials. Tuning parameters such as the shape, size, and elemental composition of nanomaterials has allowed scientists to ...
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(2011-01-10)Department: ChemistryThe continual spread of diseases, such as tuberculosis and influenza, which primarily affect poverty-stricken areas, could be slowed if suitable diagnostic resources were to become available. This dissertation examines the ...
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Harnessing Human Milk Oligosaccharides and Ellagic Acid Glycosides to Combat Group B Streptococcus (2021-03-08)Department: ChemistryGroup B Streptococcus (GBS) is a bacterium ubiquitous in human health that acts as both commensal and pathogen. While adults are often passively colonized with GBS, infants are particularly susceptible to invasive GBS ...