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Now showing items 21-30 of 64
Composition, Regulation, and Function of Protein Serine/Threonine Phosphatase•Kinase Signaling Modules
(2014-04-14)
The macromolecular assembly of protein serine/threonine phosphatase•kinase complexes mechanistically enhances the speed and fidelity of cell signaling events. These signaling modules allow for acute regulation of substrates ...
Development of Polyurethanes for Analysis and Treatment of Cancer Induced Bone Disease
(2014-04-15)
Overall cancer fatalities have stabilized since the early 1990s, however the prevalence of cancer is still remarkably high for men (45%) and women (38%). While the recent advances in treatments for cancers have increased ...
Matrix Mechanical Properties and the Invasive Potential of Metastatic Cancer
(2011-04-14)
Recent studies suggest that cancer cells undergo genotypic and phenotypic changes in response to the rigidity of the extracellular matrix (ECM). These studies have focused largely on non-mineralized tissues in the kPa range ...
A Comprehensive Framework for Systems Immune Monitoring in Patients with Cancer
(2018-03-29)
The immune system is a complex network of cells spread throughout the body, spanning dozens of tissue types and locations. A complete understanding of a systemic immune response, like those required for the regression of ...
Quantitative In Vitro and In Vivo Characterization of Near Infrared Molecular Imaging Agents for Enhanced Disease Detection
(2007-04-13)
The emerging field of molecular imaging (MI) aims to noninvasively, quantitatively and repetitively monitor biological processes in vivo to detect disease, probe its basis, and study relevant biochemical pathways at the ...
Characterizing the role of the Est1 protein in stimulating the recruitment of the Est3 protein to the yeast telomerase complex
(2012-06-11)
Telomeres are protective protein/DNA complexes that cap the ends of linear chromosomes. The repetitive, TG-rich telomeric sequences are elongated by the telomerase ribonucleoprotein. In Saccharomyces cerevisiae, the ...
Pro and Anti Tumorigenic Effects of EPHA Receptor Signaling in Breast and Lung Cancer
(2010-04-10)
The Eph family of receptor tyrosine kinases has important roles in multiple aspects of cancer development and progression. Substantial advances have been made in understanding the Eph receptor signalling in the pathways ...
Fluorescence Lifetime Imaging of NAD(P)H Distinguishes Pathways of Metabolic Inhibition
(2016-03-28)
Fluorescence lifetime imaging microscopy (FLIM) of the metabolic co-enzyme nicotinamide adenine dinucleotide (NAD(P)H) non-invasively probes metabolic protein-binding dynamics without the need for exogenous dyes. FLIM ...
High Affinity Peptide Neurotoxin Quantum Dot Conjugates for Detecting Endogenous Targets in Live Cells and Ex Vivo Tissue
(2009-06-05)
This project focused upon advancing nanotechnology for applications in biological assays using highly fluorescent nanocrystals, quantum dots, with high affinity peptide neurotoxins as targeting molecules. Specifically, ...
In vivo characterization of the role of histone deacetylase 3 in metabolic and transcriptional regulation
(2008-05-30)
Histone deacetylase 3 (HDAC3) is the enzymatic component of transcriptional repression complexes recruited by the nuclear hormone receptors. Inactivation of HDAC3 in cancer cell lines triggered apoptosis, and removal of ...