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A Computational Analysis on Gene Fusions in Human Cancer
(2014-07-22)
Gene fusions are instances where two discrete genes incorrectly join together. They are common mutations in cancer, and, since the advent of next generation sequencing technology, many gene fusions in cancer tissues have ...
Harnessing Non-invasive Imaging and Modeling towards Early Detection of Tumor Resistance to Targeted Therapy
(2017-02-03)
Clinical imaging and biopsies are major tools for cancer diagnosis. We explore whether serial imaging coupled with a mathematical model could test and refine patient specific forecasts for therapy outcomes.
We first ...
Total Synthesis of a Bicyclo[1.1.0]butane Fatty Acid and Biosynthetically Empowered Investigation of the Biological Activity of Apoptolidin
(2013-03-01)
Complex secondary metabolites from diverse life forms play key roles in mediating many biological processes but the exact nature of their function is often unknown. Chemical synthesis can be utilized to access such compounds ...
Evaluation of Autodock Vina for use in fragment-based drug discovery
(2013-03-01)
The most common approaches to treatment of cancer are chemo- and radiation-therapies that cause DNA damage. The efficiency of these treatments is reduced over time because cells up-regulate DNA damage response and repair. ...
Epigenetic and Transcriptional Response to HDAC Inhibition in Triple Negative Breast Cancer Cells
(2016-03-11)
Evidence suggests that chromatin-modifying complexes contribute to the uncontrolled cell proliferation of cancer cells through dysregulation of the epigenome. Histone deacetylases (HDACs) are a type of chromatin modifying ...
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho
(2007-04-06)
Integration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal cell growth, motility and adhesion. Here, we describe novel roles for p120 catenin (p120) and p190RhoGAP that coordinate ...
Oxidative metabolism of exocyclic DNA adducts
(2008-03-13)
Multiple exocyclic DNA adducts arise from reactions of lipid and DNA peroxidation products with DNA bases. These endogenous lesions are mutagenic; therefore, monitoring adduct levels may provide a means of assessing genomic ...
Blood vessel epicardial substance (BVES) and BVES binding partners in intestinal homeostasis and tumorigenesis
(2019-09-19)
Blood vessel epicardial substance (BVES or POPDC1) is a tight junction-associated adhesion molecule that regulates epithelial-mesenchymal transition and is downregulated in colorectal cancer via promoter hypermethylation, ...
The role of NF-kB inducing kinase (NIK) in modulating melanoma tumorigenesis
(2011-10-03)
Nuclear factor-êB (NF-êB) inducing kinase (NIK) is a MAP3K that regulates activation of NF-êB. NIK is often over-expressed in tumor cells, including melanoma, but the significance of this in melanoma progression remains ...
Role of Host Cell Factor-1 in MYC-driven gene expression and tumorigenesis
(2020-12-06)
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly-validated target for development of anti-cancer therapies. It has, however, proven challenging to inhibit MYC directly. Novel strategies ...