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Development of Albumin-Hitchhiking siRNA Conjugates for Therapeutic Mcl-1 Silencing in Triple Negative Breast Cancer
(2022-05-16)
Triple negative breast cancer (TNBC) is characterized by a lack of estrogen receptor, progesterone receptor, and HER2. Patients with TNBC therefore cannot benefit from treatment with one of the molecularly targeted therapies ...
Ligand-independent integrin beta1 signaling supports lung adenocarcinoma development
(2022-07-13)
Integrins, the principal extracellular matrix (ECM) receptors of the cell, promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer ...
Self/tumor-reactive CD8 T cells enter a memory-like TCF1+ PD1- dysfunctional state
(2023-07-18)
T cells recognize several types of antigens in tumors, including aberrantly expressed, non-mutated proteins (self/shared-antigens; SSA) and mutated proteins or oncogenic viral proteins (tumor-specific antigens; TSA). ...
Self/tumor-reactive CD8 T cells enter a memory-like TCF1+ PD1- dysfunctional state
(2023-07-18)
T cells recognize several types of antigens in tumors, including aberrantly expressed, non-mutated proteins (self/shared-antigens; SSA) and mutated proteins or oncogenic viral proteins (tumor-specific antigens; TSA). ...