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Insights into the Catalytic Mechanism of Eukaryotic and Bacterial Type II Topoisomerases and the Actions of Topoisomerase II Poisons
(2015-03-13)
Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during catalysis. Because the activities of these domains are tightly linked, ...
Role of DNA interactions in modulating the activity of human topoisomerases and anticancer drugs
(2011-03-18)
Human topoisomerase I and topoisomerase IIα and IIβ play critical roles in regulating the topological state of DNA and are targets for some of the most widely prescribed anticancer drugs currently in clinical use. These ...
MTG16, a target of the t(16;21), contributes to murine lymphoid development
(2013-04-11)
The Myeloid Translocation Gene (MTG) family was first discovered through the (8;21) translocation that leads to acute myeloid leukemia by fusing nearly all of Myeloid Translocation Gene 8 (MTG8) to an N-terminal portion ...
Discovery of small molecule inhibitors of immune checkpoint proteins
(2019-03-15)
CTLA-4 and PD-1 are immune checkpoints that inhibit T cell activity to maintain immune homeostasis. These checkpoints have also emerged as highly validated cancer targets to stimulate immune responses against cancer. Despite ...
Structure-function studies of Jhd2, a histone H3K4 demethylase
(2011-03-21)
Histone lysine (K) methylation is a dynamic process that plays an important role in regulating chromatin structure and gene expression. This study has identified Jhd2, a JmjC domain-containing protein, as an H3K4-specific ...
Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer's Disease
(2013-09-23)
Biochemistry
Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein
C-Terminal Fragment C99 and the Etiology of Alzheimer’s Disease
Paul John Barrett
Dissertation under the direction of Professor ...
Functional annotation of orphan human P450 enzymes: heterologous expression and substrate searches by metabolomic approaches
(2014-09-16)
Cytochrome P450s are versatile biocatalysts that play crucial roles in many important biological processes. Functional annotation of orphan P450 enzymes is the focus of this work.
Catalytic activities of orphan human P450 ...
Formation, Degradation, and Bypass of DNA-Protein Crosslinks
(2018-09-18)
The preservation of DNA replication is requisite for cellular integrity and prevention of tumor formation and cell death. The Y-family DNA polymerases (Pol eta, kappa, iota, and REV1) are crucial in this process because ...
The mechanisms by which apoptotic neurons in the developing dorsal root ganglia are engulfed
(2014-10-01)
During development of the nervous system, approximately 50% of the neurons generated undergo apoptosis as part of a normal pruning process. The neuronal corpses must be efficiently cleared to prevent an immune system ...
DNA Lesions as Cellular Poisons of Topoisomerase II-alpha
(2005-11-02)
Topoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...