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Exploring two new modalities of topoisomerase II-targeting drugs to enhance specificity for cancer cells
(2019-01-18)
Type II topoisomerases are enzymes that transiently cut the DNA to regulate supercoiling and remove knots and tangles from the genome. Although they are essential for cell survivability, these enzymes are potentially ...
The Essential Role of p73 in Multiciliated Cell Development
(2016-03-18)
The pivotal role of the transcription factor p53 in tumor suppression remains unchallenged; however, the role of its family member, p73, in normal cellular function and tumorigenesis is far from certain. The goal of this ...
Quinone Metabolites of Environmental Toxins Poison Topoisomerase IIalpha
(2007-03-31)
Topoisomerases play critical roles in maintaining DNA topology during cellular processes such as DNA replication in eukaryotes. Movement of the replication machinery through the double helix induces positive supercoiling ...
The catalytic activity of HDAC3 is necessary for a normal rate of cellular proliferation
(2012-04-06)
Histone deacetylases (HDACs) are enzymes that regulate chromatin structure through removal of acetyl groups from lysine residues on histones. HDAC3 is a unique member of class 1 HDACs that is a critical component of the ...
Elucidating the mechanism of action of selective histone deacetylase inhibitors in cancer
(2013-04-09)
Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored ...
Biochemical and structural analysis of SV40 Large T antigen: insights into chaperone mediated inactivation of retinoblastoma tumor suppressor protein
(2012-03-28)
Simian Virus 40 uses its Large T antigen protein to bind and inactivate retinoblastoma tumor suppressor proteins, yielding cell transformation. T antigen is a modular protein with four domains connected by linkers. The ...
Formation and Function of Collagen IV Sulfilimine Bonds
(2013-04-15)
Collagen IV networks are essential for animal viability, providing a stable extracellular foundation for tissue functioning. These networks contain sulfilimine bonds that covalently crosslink the C-terminal NC1 interfaces ...
NMR Resonance Assignments and Secondary Structure of a Mutant Form of the Human KCNE1 Channel Accessory Protein that Exhibits KCNE3-like Function
(2019-03-28)
KCNQ1 (Q1), a voltage-gated potassium channel, is modulated by members of the KCNE family, the best-characterized being KCNE1 (E1) and KCNE3 (E3). The Q1/E1 complex generates a channel with delayed activation and increased ...
Biochemical and structural analysis of the p58C and p68N domains of DNA polymerase alpha/primase
(2008-07-28)
The replication of DNA occurs through a complex series of steps involving the coordinated action of many proteins. DNA polymerase alpha/primase (pol-prim) is a critical DNA replication factor that synthesizes short RNA-DNA ...
Structural and functional analysis of the U-box domain of the E4B ubiquitin ligase
(2011-08-31)
Ubiquitination is a post-translational modification, that functions in a variety of cellular signaling pathways. Unlike modification with a small functional group by a single enzyme, modification by the small protein ...