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Structure-Function Analyses of Prostaglandin E2 Receptor Subtypes 1 and 3
(2012-11-21)
Prostaglandin E2 (PGE2) is a lipid autacoid, which is an oxidative metabolite of arachidonic acid synthesized by cyclooxygenase and prostaglandin E synthases. PGE2 is proposed to mediate in part the pathophysiology of ...
Modeling mammalian metabolism using novel stable isotopic techniques
(2021-08-16)
Biochemical methods to quantify gene transcript, enzyme, and metabolite levels are widely used to assess metabolic pathway regulation. Though informative and even vital in some contexts, static measurements of biomolecule ...
Regulation of pancreatic endocrine cell development through linked transcriptional and splicing programs
(2021-06-24)
To better understand how Insm1, Neurod1 and Pax6 contribute to the formation and function of pancreatic endocrine cells I performed comparative immunohistochemical, transcriptomic, functional enrichment, and RNA splicing ...
The Effects of Obesity, Weight Loss, and Weight Cycling on the Immunometabolic Properties of Mouse Adipose Tissue
(2013-04-11)
Obesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
Biomolecular Signatures of Disease via Ion Mobility and Mass Spectrometry Techniques
(2014-04-01)
Ion mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
Multiple roles for Ascorbic Acid in the Brain: Transporter Regulation, Neurotransmitter Synthesis, and Brain Endothelial Cell Stability
(2014-04-17)
The roles for ascorbic acid (ASC) in regulation of its transporter, in neurotransmitter synthesis, and in brain endothelial cell barrier permeability were investigated in the brain. First, during mouse development, levels ...
Muscle Insulin Resistance: Novel Mechanisms and New Treatment Targets
(2013-05-28)
This project investigated the significance of extramyocellular barriers to the pathogenesis of skeletal muscle insulin resistance and their potential as therapeutic targets. The goals of this dissertation were to determine ...
The role of insulin and Akt in the regulation of the norepinephrine transporter and monoamine homeostasis
(2010-07-15)
Monoamine signaling in the central nervous system plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for autonomic function in the peripheral nervous ...
Macrophages and Endothelial Cells in the Pancreatic Islet Microenvironment Promote β Cell Regeneration
(2015-07-16)
Reduced pancreatic β cell mass is a hallmark of diabetes, which makes the ability to increase or restore β cell mass a major therapeutic goal. While testing the hypothesis that increased endothelial cell signaling would ...
The Role of Physical Activity and Obesity in the Occurrence of Major Cardiovascular Events and Mortality among a Low-Income Population with Diabetes
(2014-07-22)
EPIDEMIOLOGY
The Role of Physical Activity and Obesity in the Occurrence of Major Cardiovascular Events and Mortality among a Low-Income Population with Diabetes
Kimberly R. Glenn
Dissertation under the direction of Professor ...