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The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control
(2015-12-01)
Mice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
The Role of FoxM1 in Pancreatic Beta Cell Mass Regeneration and Expansion
(2008-09-29)
MOLECULAR PHYSIOLOGY AND BIOPHYSICS
THE ROLE OF FOXM1 IN PANCREATIC BETA CELL MASS
REGENERATION AND EXPANSION
AMANDA ACKERMANN MISFELDT
Dissertation under the direction of Maureen Gannon, Ph.D.
The size of an organism’s ...
The pathophysiology and functionality of metabolic microRNAs in Type 2 Diabetes Mellitus.
(2018-10-31)
microRNAs (miRNA) have been shown to be critical players in metabolism. While most miRNAs studies have focused on their functional role within cells, miRNAs are also found extracellularly and have been proposed to participate ...
Investigations into islet pdx1 activity: contribution to mature β-cell identity and the identification and characterization of Pdx1 coregulators
(2015-05-28)
Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β-cell function. However, little is known regarding its role in mature β-cells or the positive- and negative-acting coregulators ...