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The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control
(2015-12-01)
Mice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
Transcriptional Profiling of Pancreatic Progenitor Cells
(2011-12-04)
Pluripotent stem cells, because of their ability to differentiate into any cell type, have been widely advocated as a means of producing a nearly unlimited source of new insulin-producing β cells for the treatment of ...
Tissue-specific regulation and function of Pancreatic and duodenal homeobox 1
(2006-12-04)
The transcription factor Pancreatic and duodenal homeobox 1 (Pdx1) is essential for formation of the pancreas and for glucose-responsive insulin secretion from mature pancreatic beta cells. In humans and mice, heterozygosity ...
Modulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration.
(2015-03-25)
As diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
The Role of FoxM1 in Pancreatic Beta Cell Mass Regeneration and Expansion
(2008-09-29)
MOLECULAR PHYSIOLOGY AND BIOPHYSICS
THE ROLE OF FOXM1 IN PANCREATIC BETA CELL MASS
REGENERATION AND EXPANSION
AMANDA ACKERMANN MISFELDT
Dissertation under the direction of Maureen Gannon, Ph.D.
The size of an organism’s ...
Examining the roles of MafB in the pancreatic islet
(2015-10-20)
Analysis of MafB-/- mice suggested that this transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied because these mutants ...
Regulation of pancreatic endocrine cell development through linked transcriptional and splicing programs
(2021-06-24)
To better understand how Insm1, Neurod1 and Pax6 contribute to the formation and function of pancreatic endocrine cells I performed comparative immunohistochemical, transcriptomic, functional enrichment, and RNA splicing ...