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The role of leptin in macrophage-driven aortic root lesion formation and of macrophage inflammatory protein-1α in leukocyte infiltration of white adipose tissue
(2009-12-11)
Obesity is a strong risk factor for type 2 diabetes and cardiovascular disease partly because of the changes that occur in white adipose tissue (WAT) during weight gain. As obesity progresses, WAT expands, becomes ...
Tissue-specific regulation and function of Pancreatic and duodenal homeobox 1
(2006-12-04)
The transcription factor Pancreatic and duodenal homeobox 1 (Pdx1) is essential for formation of the pancreas and for glucose-responsive insulin secretion from mature pancreatic beta cells. In humans and mice, heterozygosity ...
Autoreactive B cell development in the periphery
(2006-10-09)
Self-reactive B lymphocytes are frequently produced as a consequence of B cell antigen receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by tolerance mechanisms survive and mature in the ...
The Role of FoxM1 in Pancreatic Beta Cell Mass Regeneration and Expansion
(2008-09-29)
MOLECULAR PHYSIOLOGY AND BIOPHYSICS
THE ROLE OF FOXM1 IN PANCREATIC BETA CELL MASS
REGENERATION AND EXPANSION
AMANDA ACKERMANN MISFELDT
Dissertation under the direction of Maureen Gannon, Ph.D.
The size of an organism’s ...
Pyridoxamine protects against glucose-induced protein damage
(2006-04-12)
Non-enzymatic modification by glucose of proteins induces protein damage through the formation of advanced glycation end products (AGEs). AGEs have been implicated in the pathogenesis of a number of diseases including ...
The Relationship Between Diabetes and Depressive Symptoms in the Southern Community Cohort Study
(2005-04-19)
The goal of this study was to examine the relationship between diabetes and depressive symptoms in the Southern Community Cohort Study (SCCS). The SCCS is a prospective, community-based cohort study examining racial ...
Analysis of Methylglyoxal Toxicity in Hybridoma Cell Culture
(2004-04-09)
Methylglyoxal (MG) is a toxic compound which is produced in cells as a byproduct of glycolysis. Recently, the compound has been suggested as a damaging agent in batch cultures of production cell lines. In the current ...