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Extracellular Vesicles: Mechanisms of Cargo Selection and Cell-Cell Communication
(2021-03-25)
Extracellular vesicles (EVs) are mediators of cell-cell communication and play important roles in many physiological processes including cancer and drug resistance. EVs are nanosized particles secreted from every cell, ...
A Performance and Storage Evaluation of Lightweight Containerization with NixOS
(2021-03-29)
Current solutions for software deployment in cloud computing and high performance computing (HPC) incur a significant amount of storage overhead in order to allow scalability while guaranteeing reproducibility. Containerization, ...
The role of HIF signaling during Staphylococcus aureus osteomyelitis and biomaterial-based treatment strategies
(2021-03-25)
Osteomyelitis, inflammation of bone, is highly morbid and is most commonly triggered by Staphylococcus aureus infection. Despite the introduction of antimicrobials, curative treatment of S. aureus osteomyelitis often fails ...
A CHEMICAL BIOLOGY APPROACH TO UNDERSTANDING CELLULAR MANGANESE HOMEOSTASIS IN THE BRAIN
(2021-04-02)
Manganese (Mn) is a biologically essential metal, critical as a cofactor for numerous enzymes such a glutamine synthetase and kinases such as ataxia-telangiectasia mutated (ATM). Similar to other essential metals, such as ...
Targeting Gli-Mediated Transcription in Bone Metastasis: An Emerging Therapeutic Approach for Patients with Tumor-Induced Bone Disease
(2021-03-29)
Bone is a common site of metastasis for advanced breast, prostate, and lung cancer. Most patients with skeletal metastases develop tumor-induced bone disease (TIBD), which is characterized by a vicious cycle of tumor growth ...
Optimized Synthesis of Mechanochemically Generated Metal Complexes
(2021-03-25)
Solvent-based synthesis has been the foundation of chemistry since the inception of synthetic transformations. As chemists become more aware of the chemical and environmental complications that arise from the use and ...
Realizing Directional, Narrowband Thermal Emission through Control of Spectral Dispersion and Strong Coupling
(2021-05-17)
The mid-to long-wave infrared (λ~2.5– 12 µm) is home to a large number of fundamental molecular vibrations as well as two atmospheric transmission windows (λ ~ 3–5 and 8–12 µm). Accordingly, research focused on developing ...
The Social Construction of COVID-19 Through Historical Comparisons to SARS and Other Epidemics in News Media Coverage
(2021-03-25)
Because of news media’s role in information dissemination and communication, researchers believe that news media plays a significant role in social construction, the process by which meaning and value are attributed to ...
Sowing Fresh Seeds on Scorched Earth: A Systematic Interpretation of the Concept of Bildung in G.W.F. Hegel's Philosophy
(2021-03-27)
G.W.F. Hegel’s political thought took shape in response to the two great democratic revolutions of his lifetime (France, Saint-Domingue). Although Hegel sympathized with aspects of both rebellions, his final judgment was ...
For Too Long We Have Known Violence, Now We Want Peace. The Struggle to End Armed Conflict in the Colombian Department of Chocó
(2021-03-31)
In 2016, former Colombian President Juan Manuel Santos struck a peace deal with the Fuerzas Armadas Revolucionarias de Colombia – Ejército del Pueblo (FARC-EP) which brought an end to the guerrilla group’s prolonged ...