Optimized Synthesis of Mechanochemically Generated Metal Complexes
Speight, Isaiah Ray
0000-0002-5420-5891
:
2021-03-25
Abstract
Solvent-based synthesis has been the foundation of chemistry since the inception of synthetic transformations. As chemists become more aware of the chemical and environmental complications that arise from the use and disposal of solvents, new methods have been developed to circumvent these issues, one of which is mechanochemistry. Mechanochemical methods, particularly those involving grinding and milling, have given chemists new tools to utilize in efforts to minimize or avoid solvent use and waste. Circumventing the use of solvents with mechano-chemical methods has also led to advancements in inorganic and organometallic synthesis. An improved preparation of the synthetically important reagent calcium bis(trimethylsilyl)amide, [Ca(N(SiMe3)2], was developed that exploit-ed non-stoichiometric ratios of reagents, and afforded the product in good yield in 10 minutes, free of contaminating calciate species. A mercury(II) imidazolate (Hg(Im)2) framework of square grid (sql) topology was discovered, as well as supporting evidence for C–H···Hg agostic interactions between layers. This species was also the first report-ed example of disappearing polymorphism in a metal-containing species. Advancements to the area of Grignard chemistry were made by the implementation of mechanochemical methods to showcase the activation of carbon-fluorine bonds in homocoupling reactions. Lastly, new ligands for metal allyl compounds that can be utilized in mechanochemical synthesis were investigated. In early results, it was observed that in addition to an improved syn-thesis of a 1,3-tert-butyl substituted allyl precursor, mechanochemistry could also be used at various stages as a solvent-free alternative to the traditional solution-based methods.
Files in this item
This item appears in the following collection(s):
Related items
Showing items related by title, author, creator and subject.
-
Kennedy, Jack Phillip (2010-08-09)Department: ChemistryThe content described in detail in this dissertation covers natural product guided drug discovery, traditional hit-to-lead medicinal chemistry and advances in total synthesis. The synthesis and biological evaluation of ...
-
Das, Gaurav (2015-07-31)Department: Chemical EngineeringOver the last 25 years, the statistical associating fluid theory (SAFT) has been developed and refined in order to describe the thermophysical properties and phase behavior of a wide range of pure fluids. These include for ...
-
van der Ende, Alice Elizabeth (2010-06-07)Department: ChemistryWhile traditional polyesters, such as poly(lactic acid) and poly(glycolic acid), have long been of interest for the development of nanoparticles as effective drug delivery devices, they are restricted in their utility due ...