Browsing Electronic Theses and Dissertations by Department "Chemical and Physical Biology"
Now showing items 1-20 of 67
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(2014-06-25)Department: Chemical and Physical BiologyThe methylation state of DNA is important for gene expression, gene imprinting, X-chromosome inactivation, and transposon silencing in mammals and plants. DNA methylation is established by methyltransferases to mark a ...
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(2016-04-11)Department: Chemical and Physical BiologyThe goal of the presented work is to develop robust magnetic resonance imaging (MRI) techniques to improve current and enable future applications of thermal therapies. Focused ultrasound therapy is an emerging treatment ...
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(2019-03-28)Department: Chemical and Physical BiologyThe FV region of an antibody consists of the heavy chain (HC) and light chain (LC) variable domains whose association is maintained by a series of conserved, non-polar interactions. During chronic infections, somatic ...
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(2013-07-29)Department: Chemical and Physical BiologyWith the development of anti-cancer therapies that specifically target the tumor and its microenvironment, the current radiographic analysis of treatment response that uses one-dimensional changes in tumor size may not be ...
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(2011-12-09)Department: Chemical and Physical BiologyStructural information facilitates understanding of protein function and activity. The limitations of experimental methods for protein structure elucidation in applicability to certain types and families of proteins, ...
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(2019-03-25)Department: Chemical and Physical BiologyCells constantly sense and respond to cues via signaling networks. These networks operate in dynamic systems and often serve multiple purposes, translating multiple inputs into multiple outputs depending on context. Because ...
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(2016-04-04)Department: Chemical and Physical BiologyOver the past 30 years, childhood obesity in the US has nearly doubled, while obesity has tripled among adolescents. Given critical differences in neural function between adults and children, we studied children to better ...
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(2018-04-10)Department: Chemical and Physical BiologyModern single-cell technologies allow multiplexed sampling of cellular states within a tissue. However, computational tools that can infer developmental cell-state transitions reproducibly from such single-cell data are ...
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(2018-04-23)Department: Chemical and Physical BiologyBioactive natural products are small molecules produced by organisms of all domains to influence and respond to environmental conditions. These molecules have evolved to recognize both intra and inter cellular targets and ...
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(2010-04-30)Department: Chemical and Physical BiologyIn this thesis, the structural differences between wild-type band 3 and band 3 Fukuoka, the G130R mutant identified in cases of hereditary spherocytosis associated with reduction of protein 4.2, are examined. The G130R ...
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(2019-07-24)Department: Chemical and Physical BiologyThe blood-brain barrier (BBB) is a highly restrictive and regulated vascular network, strictly controlling the molecules that enter the brain via the bloodstream, while also serving an important role in the removal of toxic ...
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(2016-07-29)Department: Chemical and Physical BiologyMetals, such as iron, zinc, and manganese, are required for bacterial function and survival. Bacteria have evolved systems to acquire metals from the environments they inhabit. Pathogenic bacteria must obtain metals from ...
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(2015-02-26)Department: Chemical and Physical Biology2-Amino-3-methylimidazo-[4,5-f]quinoline, IQ, has been identified as one of the most genotoxic materials according to Ames assays and animal studies. IQ is during high temperature cooking of meats and is classified as ...
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(2019-02-12)Department: Chemical and Physical BiologyReplication of our genes requires unwinding of DNA and generating the new complementary strands for both leading and lagging parental strands. The DNA polymerases that generate the complementary strands require a short ...
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(2009-12-08)Department: Chemical and Physical BiologyThe premise of this work is to understand the contrast variations seen in MRI in light of the proteomic composition of tissue. Magnetic resonance imaging (MRI) is now widely used as a primary medical imaging method to ...
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(2011-03-14)Department: Chemical and Physical BiologyIn the course of this dissertation a software EM-Fold was developed that combines de-novo protein structure prediction and medium resolution cryoEM density maps. It can be applied to proteins containing α-helices and ...
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(2015-03-26)Department: Chemical and Physical BiologyClostridium difficile is a common nosocomial infection that encompasses a range of clinical symptoms from mild diarrhea to complicated pseudomembranous and fulminant colitis. C. difficile secretes two large toxins, TcdA ...
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Design and Characterization of a Microfluidic System for Scanning Transmission Electron Microscopy (2010-06-29)Department: Chemical and Physical BiologyFor years it has been a goal to image biological specimens in liquid in the electron microscope, avoiding possible artifacts introduced by sample preparation procedures. Here, I present a microfluidic system that allows ...
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(2012-08-06)Department: Chemical and Physical BiologyThe structural analysis of the sodium-calcium exchanger NCX1.1 is presented in this thesis. I explore the background information and previous research detailing NCX1.1 and its mechanism. I also explain some of the technical ...
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(2011-12-08)Department: Chemical and Physical BiologyThe adaptor protein ankyrin-R interacts via its membrane binding domain with the cytoplasmic domain of the anion exchange protein (AE1) and via its spectrin binding domain with the spectrin based membrane skeleton in human ...