Browsing Electronic Theses and Dissertations by Department "Neuroscience"
Now showing items 21-40 of 223
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(2010-04-07)Department: NeuroscienceCalcium/calmodulin-dependent kinase II (CaMKII) facilitates L-type calcium channel (LTCC) activity physiologically, but may exacerbate LTCC-dependent pathophysiology. We previously showed that CaMKII forms stable complexes ...
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(2010-03-29)Department: NeuroscienceRolling Blackout (RBO), a Drosophila EFR3 homolog, is an integral membrane protein predicted to be a lipase. A conditional temperature-sensitive (TS) mutant (rbots) displays paralysis following a 25-37oC temperature shift, ...
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(2016-11-29)Department: NeuroscienceAlzheimer’s disease (AD) is the most common form of dementia. There is currently no treatment that will delay, halt, or prevent the onset of AD. If a disease modifying therapy were to be implemented, it has been proposed ...
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(2017-10-04)Department: NeuroscienceEpileptic encephalopathies (EEs) are a devastating group of severe childhood onset epilepsies with medication resistant seizures and poor developmental outcomes. Many EEs have a genetic etiology and are often associated ...
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(2023-08-15)Department: NeuroscienceThe insular cortex (IC) integrates sensory and interoceptive cues to inform downstream circuitry executing adaptive behavioral responses. The IC communicates with areas involved canonically in stress and motivation. IC ...
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(2023-03-27)Department: NeuroscienceEpilepsy is one of the most common neurological disorders, and current treatments fail to provide seizure control for ~30% of patients. Most pharmacological treatments target ion channels and neurotransmission, yet the ...
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(2022-11-22)Department: NeuroscienceAutism has long been considered an empathy related condition, yet empirical evidence supporting this claim has been inconclusive. While most cognitive empathy assessments suggest a decreased capacity for emotion recognition, ...
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Characterizing Rare Disease-Causing Mutations in Genes Affecting Cation-Coupled Chloride Cotransport (2020-03-27)Department: NeuroscienceSeveral human diseases have been associated with mutations in genes affecting cation-chloride cotransporters. My dissertation characterizes two single clinical cases with mutations in genes encoding protein kinase D1 (PKD1) ...
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(2021-04-12)Department: NeuroscienceArabic digits are perhaps the most ubiquitous symbol set used regardless of one’s native language and script. The ability to read numerals fluently is critical to succeed in the modern world. Yet, we know very little about ...
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(2016-06-27)Department: NeuroscienceThe trigeminal somatosensory system conveys the sense of touch to the face. Most mammals have specialized tactile hairs, or whiskers, on their cheeks and chin that mediate tactile exploration of their environment. These ...
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(2013-04-03)Department: NeuroscienceInsights into the organization of vertebrate nervous systems have often arisen through systematic examinations of specific behaviors and their possible neural substrates. This approach is even more effective when diverse ...
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(2006-11-01)Department: NeuroscienceCommon diseases with a genetic basis are likely to have a very complex etiology, in which the mapping between genotype and phenotype is far from straightforward. A new comprehensive statistical and computational strategy ...
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(2021-05-11)Department: NeuroscienceAlcohol use disorder (AUD) affects over 15 million Americans and remains exceptionally difficult to treat, with the majority of individuals relapsing within a year of initiating treatment. Much of this difficulty is thought ...
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(2009-08-11)Department: NeuroscienceDissertation under the direction of Professor Edwin J. WEeber Apolipoprotein E (apoE) interacts with lipoprotein receptors in the hippocampus. These receptors are intimately involved in the modulation of synaptic plasticity, ...
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(2017-11-29)Department: NeuroscienceContributions of Metallo-Beta-Lactamase Domain Containing Protein 1 (MBLAC1) to the Neurobiological Actions of Ceftriaxone Cassandra Lynn Retzlaff Dissertation under the direction of Professor Randy Blakely, PhD Recently ...
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(2013-09-30)Department: NeuroscienceObesity and obesity-associated disease together are a leading cause of death worldwide. Recent research demonstrates striking similarities between obesity and addiction in their dysregulation of brain dopamine systems. ...
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(2005-12-05)Department: NeuroscienceOur aged population is poised to expand dramatically within the next decade. In Alzheimer’s disease (AD) pathogenesis studies, the end point hallmarks or lesions are known and well studied; however, the exact processes leading ...
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(2021-05-11)Department: NeuroscienceStress is critical to every organism’s ability to adapt and survive. This dissertation reviews the history of stress research and reviews stress physiology across a variety of organ systems. Neurocircuitry that is involved ...
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(2019-07-24)Department: NeuroscienceFoxg1 Disorder is a rare yet devastating neurodevelopmental disorder that is characterized by intellectual, motor, and social deficits as well as seizures. It is accompanied by neuroanatomical abnormalities. The protein ...
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(2021-09-10)Department: NeuroscienceSepsis is a life-threatening illness characterized by acute organ dysfunction including encephalopathy that clinically manifests as delirium. Survivors experience persistent cognitive deficits that indicate lasting ...