Browsing Electronic Theses and Dissertations by Department "Pharmacology"
Now showing items 81-100 of 143
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(2015-07-17)Department: PharmacologyNeurofibromatosis type 1 (NF1) is the most common autosomal dominant genetic disorder occurring in 1 of every 3500 live births. NF1 is caused by loss-of-function mutations in NF1, the gene encoding the Ras-GAP neurofibromin. ...
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(2011-08-05)Department: PharmacologyArrestins are multifunctional signaling proteins, important for the regulation of signal transduction and the trafficking of G protein-coupled receptors (GPCRs). Recently, GPCR-arrestin interactions have been proposed to ...
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(2016-10-19)Department: PharmacologyReduced platelet aggregation and a mild bleeding phenotype has been observed in patients chronically taking selective serotonin reuptake inhibitors (SSRIs) that block the serotonin transporter (SERT). Here, I explore this ...
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(2016-04-26)Department: PharmacologyDysregulation of the mesolimbic dopamine (DA) system is a hallmark of the pathophysiology of drug addiction and many other prevalent diseases. The nucleus accumbens (NAc), a region essential for the incentive and hedonic ...
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(2014-05-28)Department: PharmacologyInward rectifier potassium (Kir) channels are a family of two transmembrane-spanning potassium selective ion channels. Kir channels are found in all kingdoms of life where they play essential roles in regulating numerous ...
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(2019-03-19)Department: PharmacologyFluoroquinolones are among the most widely prescribed antibacterials worldwide. However, their usefulness is being diminished by the rise in drug resistance. The most common and detrimental form of fluoroquinolone resistance ...
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(2016-11-30)Department: PharmacologyHighly reactive acyclic levuglandin-like gamma-ketoaldehydes (gamma-KA, isoketals, or IsoKs) are formed as products of the isoprostane pathway of lipid peroxidation. IsoKs are known to covalently adduct ε-amino groups in ...
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(2014-04-19)Department: PharmacologyThe dietary polyphenol curcumin shows great promise as an anti-cancer and anti-inflammatory agent. While many cellular targets of curcumin have been identified, the chemical mechanisms whereby these targets are affected ...
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(2018-05-17)Department: PharmacologyPatients with resistant hypertension have uncontrolled blood pressure despite concurrent treatment with three or more antihypertensive medications including a thiazide diuretic. Compared to patients with controlled ...
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(2020-11-16)Department: PharmacologyMalignant migrating partial seizures of infancy is a rare, devastating form of epilepsy most commonly associated with gain-of-function mutations in the potassium channel, Slack. Not only is this condition almost completely ...
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(2014-03-18)Department: PharmacologyPHARMACOLOGY Pharmacological and Genetic Rescue of Idiopathic Epilepsies Lyndsey Leigh Anderson Dissertation under the direction of Professor Alfred George, Jr. Epilepsy is a common neurological disorder affecting ...
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(2013-08-06)Department: PharmacologyAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults. The discovery of mutations in familial AF illustrated the contribution of specific genetic factors to AF susceptibility and suggested ...
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(2017-12-04)Department: PharmacologyCardiac arrest is a leading cause of death. Even with the best cardiopulmonary resuscitation (CPR), many patients still die or suffer severe organ damage. The reintroduction of blood flow at the start of CPR after systemic ...
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(2020-03-13)Department: PharmacologyIn psychiatric disorders including posttraumatic stress disorder (PTSD) and schizophrenia, dysfunction of the prefrontal cortex (PFC) is associated with cognitive and emotional deficits that involve aberrant afferent ...
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(2022-01-04)Department: PharmacologyMethyl-CpG-Binding Protein 2 (MECP2)-related neurodevelopmental disorders, including Rett syndrome (RTT), MECP2 Duplication syndrome (MDS) and Pitt-Hopkins syndrome (PTHS) are rare, pediatric diseases with devastating ...
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(2008-12-02)Department: PharmacologyCa2+ activated signaling pathways coordinate contraction in the heart, but these pathways cause disease upon excessive activation. Intracellular Ca2+ activates the multifunctional Ca2+ and calmodulin dependent protein ...
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(2021-08-13)Department: PharmacologyMetabotropic glutamate receptor 4 (mGlu4) is one of eight mGlu receptors within the Class C G protein-coupled receptor superfamily. mGlu4 is primarily localized to the presynaptic mem¬brane of neurons where it functions ...
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(2013-07-31)Department: PharmacologyAdrenal chromaffin cells release catecholamines, neuropeptides and other hormones to maintain cardiovascular and metabolic homeostasis, and tune the physiological response to acute stress. As such, chromaffin cells represent ...
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(2011-04-07)Department: PharmacologyDuring vertebrate development, neural crest (NC) cells migrate from the dorsal neural tube and generate a wide variety of cell types throughout the embryo including neurons, glia, melanocytes, smooth muscle, cartilage and ...
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(2012-12-01)Department: PharmacologyStudies described in this thesis identify a novel mechanism for α4’s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown ...