Browsing Electronic Theses and Dissertations by Department "Cell and Developmental Biology"
Now showing items 61-80 of 179
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(2010-08-02)Department: Cell and Developmental BiologyThis project provides a detailed characterization of the CLASP-dependent microtubule array at the Golgi in terms of function and regulation. First, I briefly outline the process of MT nucleation at the Golgi and highlight ...
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(2014-03-29)Department: Cell and Developmental BiologyMicrotubule-associated proteins (MAPS) frequently influence microtubule (MT) dynamics and may also alter MT-dependent processes, such as protein trafficking. RASSF1A is a MAP that is frequently silenced in most human ...
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(2013-04-19)Department: Cell and Developmental BiologyNinjurins are a conserved family of transmembrane proteins that increase expression in response to injury and stress. There are few in vivo studies of Ninjurin, and little is known about Ninjurin function. In this thesis ...
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(2005-11-07)Department: Cell and Developmental BiologyProper function of the brain requires that neurons adopt different morphologies and connections. In the nematode <i>C. elegans</i>, VA and VB motor neurons arise from a common precursor cell but adopt different morphologies ...
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(2011-07-21)Department: Cell and Developmental BiologyThe <i>C. elegans</i> genome has been completely sequenced, and the developmental anatomy of this model organism is described at single-cell resolution. Here we utilize strategies that exploit this precisely defined ...
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(2010-12-04)Department: Cell and Developmental BiologyThe spatiotemporally dynamic distribution of instructive ligands within embryonic tissue, and their feedback antagonists, including inherent stabilities and rates of clearance, are affected by interactions with cell surfaces ...
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(2015-07-23)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY Identification and characterization of MAFA coregulators: MLL3/4 and its role in mouse and human islet β-cells David William Scoville Dissertation under the direction of Professor Roland ...
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(2017-04-04)Department: Cell and Developmental BiologyApico-basolateral polarity is a fundamental property of epithelial cells, and its loss is a hallmark of colorectal cancer (CRC). Role(s) for lateral integrins in this polarization process and the consequences of their ...
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(2016-03-30)Department: Cell and Developmental BiologySpasmolytic polypeptide-expression metaplasia (SPEM) develops in the atrophic stomach and progresses to an intestinalized SPEM in the setting of inflammation. Different immune deficient mouse models determined that T-cells, ...
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(2016-10-12)Department: Cell and Developmental BiologyEnterocytes, epithelial cells of the small intestine, exhibit remarkable apical-basal polarity. The apical surfaces of enterocytes display an array of tightly packed microvilli termed the brush border. Microvilli are ...
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(2010-09-21)Department: Cell and Developmental BiologyThis dissertation project was aimed at elucidating cellular and molecular responses to myocardial infarction. Our work identified canonical wnt signaling as a molecular pathway that is induced in the healing (granulation ...
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(2013-07-11)Department: Cell and Developmental BiologyNeurodegenerative diseases are characterized by inappropriate death of distinct neuronal populations. Although symptoms vary, these diseases share pathogenic features such as age-dependent onset and progressive death of ...
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(2013-12-09)Department: Cell and Developmental BiologyDuring liver development, precise signaling is required to direct cell fate decisions and architectural establishment. It is hypothesized that the same signaling pathways are important in directing liver regeneration. To ...
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(2016-07-25)Department: Cell and Developmental BiologyThe Wnt signaling pathway plays essential roles in a wide variety of biological processes including early animal development, cell fate determination, cell proliferation, organogenesis, and stem-cell renewal. Deregulation ...
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(2010-08-03)Department: Cell and Developmental BiologyOne Immunological disorders of the gastrointestinal tract is inflammatory bowel disease (IBD). IBD results in recurrent and persistently elevated levels of cytokines, such as tumor necrosis factor (TNF). TNF promotes ...
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(2016-07-22)Department: Cell and Developmental BiologyDuring mouse embryogenesis, organ formation is accomplished through a close coordination between genetically encoded programs of proliferative growth, differentiation, and morphogenesis in organ-specific progenitor ...
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(2014-11-26)Department: Cell and Developmental BiologyCerebellar growth and foliation require the Hedgehog-driven proliferation of granule cell precursors (GCPs) in the external granule layer (EGL). However, that increased or extended GCP proliferation generally does not ...
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(2007-03-23)Department: Cell and Developmental BiologyTransient asymmetric Nodal signaling in the left lateral plate mesoderm (L LPM) during tailbud/early somitogenesis stages is associated in all vertebrates examined with the development of stereotypical left-right (L-R) ...
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(2019-09-17)Department: Cell and Developmental BiologyThe intestinal brush border lines the apical surface of enterocytes and is composed of thousands of actin-supported protrusions called microvilli, which extend into the intestinal lumen. Microvilli function to increase ...
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(2018-03-29)Department: Cell and Developmental BiologyThe intestinal brush border serves as the sole site of nutrient absorption within the body, and also acts as an important barrier against luminal pathogens. The brush border is comprised of membrane protrusions called ...