• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDepartmentThis CollectionBy Issue DateAuthorsTitlesSubjectsDepartment

    My Account

    LoginRegister

    Inflammatory Mediators promote the development and progression of metaplasia in the stomach

    Petersen, Christine Pope
    : https://etd.library.vanderbilt.edu/etd-03172016-151927
    http://hdl.handle.net/1803/10842
    : 2016-03-30

    Abstract

    Spasmolytic polypeptide-expression metaplasia (SPEM) develops in the atrophic stomach and progresses to an intestinalized SPEM in the setting of inflammation. Different immune deficient mouse models determined that T-cells, B-cells, IFN gamma and neutrophils are not essential for the progression to an intestinalized SPEM. However, studies using macrophage-depleted mice found that specifically M2 macrophages were necessary for SPEM to become intestinalized. Efforts to understand macrophage-derived factors that promote the advancement of metaplasia led to RNA-sequencing of gastric macrophages in the setting of SPEM and intestinalized SPEM. A novel profile of activated gastric macrophages revealed that IL-33 is significantly upregulated in the setting of intestinalized SPEM. Inducing parietal cell loss in IL33 knock out mice uncovered an essential role for IL-33 in the transdifferentiation of mature chief cells into SPEM cells. Furthermore, IL-33 is required for the polarization of recruited macrophages towards M2a. Thus establishing a vital role for IL-33 in the development of metaplasia and macrophage polarization in response to acute parietal cell loss in the stomach.
    Show full item record

    Files in this item

    Icon
    Name:
    Petersen.pdf
    Size:
    47.42Mb
    Format:
    PDF
    View/Open

    This item appears in the following collection(s):

    • Electronic Theses and Dissertations

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy