Browsing Electronic Theses and Dissertations by Department "Cancer Biology"
Now showing items 61-80 of 161
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(2017-05-11)Department: Cancer BiologyIt was been well established that the Activin A signaling pathway plays a pivotal role in the developing, adult, and diseased organism, commonly acting as a growth inhibitor. Though prevalent in embryonic tissues, Activin ...
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(2005-04-08)Department: Cancer Biologyp120 binds and is thought to regulate the cell-cell adhesion molecule E-cadherin. Experiments in a p120-deficient carcinoma cell line suggest a critical role for p120 in stabilizing E-cadherin. p120 downregulation occurs ...
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(2013-07-26)Department: Cancer BiologyLZAP (Cdk5rap3, C53) is a putative tumor suppressor lost in 30% of human head and neck squamous cell carcinoma. LZAP depletion enhances cell invasion, xenograft tumor growth and angiogenesis. Mechanistically, LZAP inhibits ...
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(2018-09-24)Department: Cancer BiologyTechnological advances have led to increasingly powerful and precise quantification of biological systems. These advances create a need for robust mathematical and computational approaches that are able to integrate complex ...
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(2012-10-31)Department: Cancer BiologyThis project was conducted to further elucidate the role of matrix metalloproteinase 7 (MMP7) in the pathogenesis of the carcinogenic bacteria Helicobacter pylori. Specifically, in this thesis I discuss the role of MMP7 ...
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(2017-07-31)Department: Cancer BiologyEvasion of cell death is essential to every step of tumorigenesis. Anti-apoptotic Bcl-2 family proteins are master inhibitors of cell death, and thus are often overexpressed in cancers. In particular, Bcl-2, Bcl-xL, and ...
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(2022-05-16)Department: Cancer BiologyBreast cancer cells frequently disseminate to bone where they proliferate or remain dormant, but the mechanisms controlling entry and exit from quiescence are largely unknown. This dissertation addresses this gap in knowledge ...
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(2011-08-30)Department: Cancer BiologyBreast cancer frequently metastasizes to the skeleton with severe consequence to patient quality of life. Patients who develop bone metastases suffer from severe bone pain and increased risk of developing hypercalcemia ...
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(2010-07-16)Department: Cancer BiologyCANCER BIOLOGY MOUSE MODELS OF PROSTATE CANCER PROGRESSION AND BONE METASTASIS Srinivas Rao Nandana Dissertation under the direction of Robert J. Matusik, PhD Prostate cancer is the second leading cause of deaths due ...
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(2010-12-22)Department: Cancer BiologyThe oncogenic PIM1 kinase has been implicated as a cofactor for the oncogene c-MYC in prostate carcinogenesis. In this study, we show that co-expression of c-MYC and PIM1 is associated with high Gleason grade in prostate ...
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(2022-07-18)Department: Cancer BiologyAberrant epithelial differentiation and regeneration contribute to colon pathologies including inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). MTG16 (CBFA2T3) is a transcriptional corepressor expressed ...
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(2007-08-06)Department: Cancer BiologyNeuroendocrine (NE) prostate cancer develops as an aggressive disease that does not respond to androgen ablation therapy. The paracrine action of NE cells can facilitate progression of androgen dependent adenocarcinoma to ...
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(2024-03-26)Department: Cancer BiologyAlthough immune checkpoint inhibition (ICI) has proven successful in treating cancer, patients with triple-negative breast cancer (TNBC) often develop therapy resistance, and the underlying mechanisms remain unclear. MHC-I ...
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(2010-06-04)Department: Cancer BiologySTRAP inhibits transforming growth factor-Beta (TGF-Beta) signaling and enhances tumorigenicity. The aim of our current research project was to identify novel TGF-Beta independent functions of STRAP. STRAP acts as a scaffold ...
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(2011-06-30)Department: Cancer BiologyThe serine threonine kinase receptor-associated protein (STRAP) is a WD40 domain protein that regulates a wide array of biological processes. Previous reports suggest that STRAP possesses oncogenic characteristics and ...
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(2015-07-23)Department: Cancer BiologyEGFR-mutant lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly occurs ...
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(2017-08-29)Department: Cancer BiologyEwing sarcoma is a highly aggressive pediatric bone tumor that is characterized EWS/FLI1 transcription factor. Ewing sarcoma tumors require the continued activity of EWS/FLI1 to sustain a gene signature that promotes ...
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(2007-04-06)Department: Cancer BiologyIntegration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal cell growth, motility and adhesion. Here, we describe novel roles for p120 catenin (p120) and p190RhoGAP that coordinate ...
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(2015-12-09)Department: Cancer BiologyIn vertebrate epithelia, p120-catenin mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial tissues typically causes striking alterations in tissue function and morphology. ...
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(2011-09-07)Department: Cancer BiologyUnderstanding how cells maintain genome integrity is necessary to gain insight into the pathology of cancer and to identify therapeutic targets and biomarkers. The DNA damage response kinase ATR is essential for the ...