Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 321-340 of 363
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(2009-10-20)Department: ChemistryAs a selective apoptosis inducer, apoptolidin A was isolated from Nocardiopsis Sp. by Japanese chemists in 1997. Khosla and coworkers have demonstrated that apoptolidin A could inhibit the activity of mitochondrial F0F1-ATP ...
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(2021-05-05)Department: ChemistryNatural products have a long history of serving as therapeutic leads (e.g. taxol and compactin) and biological tools (e.g. rapamycin and oligomycin). Bielschowskysin is a rare and structurally complex marine diterpene, ...
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Synthetic Studies on Hemiketal E2 and 5-Hydroxy Prostaglandin E2 Novel Arachidonic Acid Metabolites (2021-10-06)Department: ChemistryThe metabolites of arachidonic acid have long been studied for their intimate role in the human body inflammatory pathway. Inflammation is the body’s natural defense against foreign pathogens and maintains the body’s ability ...
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(2021-06-11)Department: ChemistryProgress toward the total synthesis of the manzamine alkaloid xestocyclamine A is described. Due to the architecturally interesting structures and biological activity of the manzamine alkaloids, xestocyclamine A remains ...
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(2011-04-16)Department: ChemistryThe development of new chemical methods to tackle synthetic challenges is presented in this dissertation. Application of these methods has led to the completion of the following projects: The first total synthesis of the ...
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(2013-09-25)Department: ChemistryThe amide bond is one of the most important linkages in organic chemistry and constitutes the key functional group in peptides, polymers, and many natural products and pharmaceuticals. Purely chemical methods have been ...
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(2010-09-06)Department: ChemistryEarly detection of pediatric viruses is critical to effective intervention. A successful clinical tool must have a low detection limit, be simple to use and report results quickly. This work describes the integration of ...
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(2021-07-20)Department: ChemistrySeveral diagnostics employ sandwich immunoassays for the detection of various infectious diseases. While some of these strategies fail to produce sensitive diagnoses for use in the field, enhancements to commercially ...
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(2024-03-18)Department: ChemistryWhile animal models are frequently used to explore the macroscale effects of various substances and processes within the blood-brain barrier (BBB), they often fail to fully recapitulate human response or prohibit mechanistic ...
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(2024-03-18)Department: ChemistryWhile animal models are frequently used to explore the macroscale effects of various substances and processes within the blood-brain barrier (BBB), they often fail to fully recapitulate human response or prohibit mechanistic ...
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(2017-03-29)Department: ChemistrySocietal challenges such as global warming and world poverty necessitate the development of alternative energy technologies which are independent of hydrocarbon combustion, utilize earth-abundant materials, and are ...
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The Effects of Quantum Dot Surface Chemistry on Fluorescence and Additive Manufacturing Applications (2019-12-06)Department: ChemistryQuantum dots (QDs), have been extensively studied for their unique optical properties, such as their lasting photostability, size-tunable band gaps, and narrow photoluminescence. Additionally, by controlling the surface ...
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(2010-06-04)Department: ChemistryFosfomycin is a broad-spectrum antibiotic that has been underused due to the nature of the resistance mounted against it by various microorganisms. The work presented here elucidates the structure function relationship ...
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(2015-03-26)Department: ChemistryThis thesis presents two avenues through which solution processable and electronically tunable QDs are investigated as active absorbers in photovoltaic applications. First, the synthesis and characterization of CuxInyS2 ...
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(2021-12-15)Department: ChemistryCyclooligomeric depsipeptides display a diverse range of biological activity and hold strong promise as potential therapeutics. However, the development of drug molecules in this larger size regime is still far less explored ...
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(2009-04-10)Department: ChemistryHemozoin (Hz), the heme detoxification biomineral formed during the intraerythrocytic stage of malaria, has long been suspected of contributing to immunomodulations that occur during P. falciparum infection. Rupture of ...
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(2009-12-16)Department: ChemistryInfecting 200 million people chronically, Schistosoma mansoni, the helminth responsible for schistosomiasis, catabolizes host hemoglobin releasing amino acids and heme. To avoid the oxidative stress caused by toxic free ...
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(2019-03-20)Department: ChemistryAlzheimer’s disease (AD) is a debilitating dementia with complex pathophysiological alterations including modifications to endogenous cysteine. S-nitrosylation (SNO) is a well-studied post translational modification (PTM) ...
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(2017-08-08)Department: ChemistryLeukotrienes and lipoxins are lipid mediators of inflammation and their biosynthesis is associated with several chronic inflammatory and cardiovascular diseases. 5-Lipoxygenase (5-LOX) and 15-lipoxygenase (15-LOX) are key ...
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(2024-03-19)Department: ChemistryAs nanochemistry grows as a field and the applications of nanomaterials emerge, the importance of understanding what happens in the reaction flask during synthesis—thinking smaller than the nanoscale level to the molecular ...