• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDepartmentThis CollectionBy Issue DateAuthorsTitlesSubjectsDepartment

    My Account

    LoginRegister

    The role of hemozoin in disease: oxidative stress

    Scott, Vanessa Jean
    : https://etd.library.vanderbilt.edu/etd-12092009-184929
    http://hdl.handle.net/1803/15227
    : 2009-12-16

    Abstract

    Infecting 200 million people chronically, Schistosoma mansoni, the helminth responsible for schistosomiasis, catabolizes host hemoglobin releasing amino acids and heme. To avoid the oxidative stress caused by toxic free heme, the heme aggregates into a biomineral known as hemozoin, which is comprised of heme molecules linked through an iron carboxylate bond. Subsequently, the schistosomes regurgitate this biomineral into the host vasculature where it is engulfed by professional phagocytes. Described in this work is the complete isolation and characterization of schistosomal hemozoin from host liver and spleen tissues and further exploration into hemozoin’s role in the pathogenesis of schistosomiasis. Hemozoin is shown to coincide with markers of oxidative stress in infected host tissue. A synthetic analogue of hemozoin, â-hematin, is demonstrated to facilitate the production of oxidative stress markers from components of cell membranes. The evidence gathered from these experiments supports the ability of hemozoin to promote oxidative stress.
    Show full item record

    Files in this item

    Icon
    Name:
    Scott_V_J_Thesis.pdf
    Size:
    1.755Mb
    Format:
    PDF
    View/Open

    This item appears in the following collection(s):

    • Electronic Theses and Dissertations

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy