Browsing Electronic Theses and Dissertations by Department "Pharmacology"
Now showing items 21-40 of 143
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(2014-04-14)Department: PharmacologyThe macromolecular assembly of protein serine/threonine phosphatase•kinase complexes mechanistically enhances the speed and fidelity of cell signaling events. These signaling modules allow for acute regulation of substrates ...
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(2010-03-31)Department: PharmacologyStriatal medium spiny neurons (MSNs) receive glutamatergic afferents from the cerebral cortex that synapse onto the spine head and dopaminergic inputs from the substantia nigra which synapse onto the necks of dendritic ...
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(2022-05-14)Department: PharmacologyCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal, stressed-induced cardiac channelopathy. CPVT is characterized by ventricular arrhythmias that are triggered by catecholamines released during exercise ...
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(2018-11-20)Department: PharmacologyCalcium and phosphate are essential elements in many biological processes, such as basic cellular function and signaling, yet they also combined to make biological crystals, most notably hydroxyapatite found in bone. ...
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(2016-03-25)Department: PharmacologyThe most widely prescribed antidepressant medications are serotonin selective reuptake inhibitors (SSRIs), believed to provide therapeutic benefit by antagonizing the serotonin transporter (5-HT; SERT), which acts to ...
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(2020-11-17)Department: PharmacologyVolume Regulated Anion Channels (VRACs) encoded by the LRRC8 gene family play critical roles in myriad cellular processes and might represent druggable targets. The dearth of pharmacological compounds available for studying ...
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(2015-07-15)Department: PharmacologyThe essential roles of glutamatergic signaling in both normal and impaired cognitive functioning have caused metabotropic glutamate (mGlu) receptors to become targets of interest for the treatment of psychiatric disorders. ...
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(2022-08-16)Department: PharmacologyBackground: The KV11.1 potassium channel, formerly the human Ether-a-go-go-Related Gene (hERG)-channel, is important for repolarization of cardiac action potentials. Loss-of-function (LOF) KV11.1 variants cause Long QT ...
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Discovery and characterization of G protein-gated, inwardly-rectifying, potassium channel modulators (2018-10-16)Department: PharmacologyG protein-gated, inwardly-rectifying, potassium (K+) (GIRK) channels are important regulators of cellular excitability throughout the body. GIRK channels are composed of four subunits and exist as homomeric and heteromeric ...
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(2005-10-19)Department: PharmacologyLipoxygenase (LOX) are non-heme iron dioxygenases that form fatty acid hydroperoxides used in membrane remodeling and cell signaling. Mammalian epidermal LOX type 3 (eLOX3) is distinctive in totally lacking this typical ...
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(2010-09-21)Department: PharmacologyThere exist five subtypes of the muscarinic acetylcholine receptor (M1-M5), which are differentially expressed throughout the body and play important roles in numerous physiological processes, including autonomic functions, ...
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(2012-04-09)Department: PharmacologyE-cadherin is a transmembrane protein that maintains intercellular contacts and cellular polarity in epithelial tissues. The down-regulation of E-cadherin is thought to aid in the induction of an epithelial-to-mesenchymal ...
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(2017-08-02)Department: PharmacologyAntibiotic resistance in bacteria is increasing globally. Urinary tract infections, which account for the majority of antibiotic prescriptions, are primarily caused by uropathogenic E. coli (UPEC). The latest report by the ...
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(2020-05-14)Department: PharmacologyIn the central nervous system, dopamine (DA) plays key roles in voluntary movement, motivation, reward, and cognition. The DA transporter (DAT) is a primary regulator of DA homeodynamics. This presynaptic membrane protein ...
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(2014-07-03)Department: PharmacologyCardiac tissue undergoes renewal with low rates. Although resident stem cell populations have been identified to support cardiomyocyte turnover, the source of the cardiac stem cells and their niche remain elusive. Using ...
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(2011-08-08)Department: PharmacologyThe field of research into endothelial progenitor cells is complex and difficult to interpret. There are a number different investigators working on specific subpopulations that are isolated in unique ways using unique ...
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(2016-11-21)Department: PharmacologyCurrent antipsychotic medications (APDs) for schizophrenia primarily treat positive symptoms (hallucinations, delusions) yet are largely ineffective in treating the negative (anhedonia, social withdrawal, apathy) and ...
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(2020-06-14)Department: PharmacologyNo current pharmacologic treatments stop the progression of Alzheimer’s disease (AD), the most common major neurocognitive disorder. High levels of cerebrospinal fluid (CSF) vascular endothelial growth factor (VEGFA) are ...
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(2011-04-06)Department: PharmacologyPHARMACOLOGY FORMATION AND METABOLISM OF 15-DEOXY-{Delta}12,14-PROSTAGLANDIN J2 IN VIVO KLARISSA D. HARDY Dissertation under the direction of Professor L. Jackson Roberts, II 15-Deoxy-{Delta}12,14-prostaglandin J2 ...
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(2011-07-29)Department: PharmacologyActivating transcription factor 4 (Atf4) is a leucine zip transcription factor. Atf4 mutant (Atf4-/-) mice show severe low bone mass and short stature phenotype. Atf4 is expressed in growth plate chondrocytes. Atf4-/- ...