Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 181-200 of 363
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(2015-11-27)Department: ChemistryVanadium dioxide (VO2) is a material that undergoes a phase transition at 68 °C which corresponds to interesting changes in its optical and electronic properties, including a decrease in resistivity of up to five orders ...
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(2013-07-29)Department: ChemistryMalaria is a disease caused by the parasite Plasmodium falciparum which kills 1-2.7 million people per year. Parasite resistance to widely available anti-malarial treatments such as Chloriquine is spreading rapidly, and ...
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(2011-12-06)Department: ChemistryThe presented research describes how properties of thiolate protected gold nanoparticles were used to create functional nanomaterials with applications in biomimetics and nanomolecular electronics. Additionally, fundamental ...
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Lead Optimization for Discovery of Potent and Selective Dopamine Receptor D<sub>4</sub> Antagonist (2015-11-27)Department: ChemistryStimulant dependence is a prolonged relapsing condition that can be exhibited by reinstatement animal models. Dopamine D<sub>4</sub> receptor antagonists are shown to interrupt drug seeking when induced by stress cues or ...
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(2015-07-21)Department: ChemistryProtein-ligand interactions are important in a variety of biological areas. The strength and location of these interactions is driven by Partial Covalent Interactions between the protein and ligand. The Rosetta framework ...
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(2005-12-05)Department: ChemistryLigand effects can play a substantial role in the stability and reactivity of organometallic complexes. For this research, sterically bulky substituents (e.g., trimethylsilyl and isopropyl groups) were incorporated as part ...
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(2019-01-02)Department: ChemistryLysophospholipase enzymes, lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2), are serine hydrolases responsible for the metabolism of three separate classes of bioactive lipid substrates, including ...
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(2011-08-03)Department: ChemistryThe focus of this work was to establish quantitative structure activity (QSAR, potency of allosteric modulators) and property (QSPR, carbon chemical shifts) relations for molecules with known structure and activity/property ...
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(2011-04-14)Department: ChemistryMALDI IMAGING MASS SPECTROMETRY FOR SMALL MOLECULE QUANTITATION AND EVALUATION FOR MARKERS OF DRUG RESPONSE IN GLIOMAS SARA L. FRAPPIER Dissertation under the direction of Professor Richard M. Caprioli A protocol has ...
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(2022-03-25)Department: ChemistryMatrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) allows for the untargeted detection of hundreds to thousands of molecular species in a single imaging experiment. Developing next-generation ...
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(2012-07-12)Department: ChemistryA series of bis(indenyl)manganese(II) complexes have been synthesized with methyl substituents. These species appear to be high spin with no-evidence of spin-crossover. However, the physical structures of these compounds ...
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(2019-03-25)Department: ChemistryPolyurethane (PU) di-block copolymers are one of the most versatile polymeric materials, commonly manufactured in the form of flexible and rigid foams, thermoplastics, thermosets, coatings, adhesives, sealants, and elastomers. ...
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(2024-03-22)Department: ChemistryHuman breast milk is the gold standard in infant nutrition. It supplies the developing neonate with nutrients, bioactive molecules, and microbes that confer total health to the infant. Human milk oligosaccharides (HMOs) ...
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(2024-03-18)Department: ChemistryAs environmental concerns over organic solvents rise and chemists become more aware of the interference solvents can play in reactions, solvent-free methods have grown in popularity, including mechanochemical methods. ...
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(2024-03-18)Department: ChemistryAs environmental concerns over organic solvents rise and chemists become more aware of the interference solvents can play in reactions, solvent-free methods have grown in popularity, including mechanochemical methods. ...
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(2021-05-26)Department: ChemistryConventional synthetic chemistry is generally facilitated by solvents that dissolve reagents and allow controlled interaction in a controlled manner, in addition to playing many other roles. However, in some cases, common ...
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(2012-12-14)Department: ChemistryRoutine analysis of cells smaller than 10 microns is a challenging task. Instruments capable of single cell analysis require advanced modifications to both laser optics and optimized instrument sensitivity to allow for the ...
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(2020-04-03)Department: ChemistryThe aim of this research was to develop methods and strategies to use advancements in ion mobility-mass spectrometry to further metabolomic research. This work describes methods that have been developed to that end, with ...
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(2009-05-20)Department: ChemistryThe biosyntheses of benzodiazepines and nitrosugar containing natural products in actinomycetes were investigated. The first biosynthetic gene cluster of a benzodiazepine natural product was identified in the genome of the ...
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(2022-05-16)Department: ChemistryWith the rise of antibiotic resistance, there is a growing need for compounds capable of non-bactericidal mechanisms that do not exert evolutionary pressure on the bacterium, such as biofilm modulators. Human milk ...