Browsing Electronic Theses and Dissertations by Department "Cell and Developmental Biology"
Now showing items 141-160 of 179
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(2013-07-29)Department: Cell and Developmental BiologyMy study of three signaling pathways in the context of three gastrointestinal diseases is presented here. Firstly, the epidermal growth factor receptor (EGFR) pathway and its role in the pathogenesis of the hypertrophic ...
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(2006-06-01)Department: Cell and Developmental BiologyConstitutively activating mutations of members of the RAS family of small G proteins provide an important oncogenic contribution to a significant percentage of human cancers. Despite nearly 25 years of investigation, ...
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(2007-11-28)Department: Cell and Developmental BiologyThe Nodal and Nodal-related morphogens are utilized for the specification of distinct cellular identity throughout development by activating discrete target genes in a concentration-dependant manner. Lefty is the principal ...
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(2010-07-14)Department: Cell and Developmental BiologyFocal adhesions (FAs) are sites at the interface between the cell and the ECM, linking integrin receptors and the actin cytoskeleton. In addition to serving as a structural platform, these sites are also robust sites of ...
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(2007-04-14)Department: Cell and Developmental BiologyThe inhibitor of DNA-binding (Id) genes encode a family of helix-loop-helix proteins lacking the basic DNA-binding domain. The Id proteins function as dominant negative factors by dimerizing with other transcription factors, ...
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(2012-12-12)Department: Cell and Developmental BiologyThe mesodermal germ layer contributes many cell types that comprise the coelomic organs during embryogenesis. One such mesodermally derived cell type is the mesothelium, which is an epithelial sheet that covers organs in ...
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The Myt1 and Ngn3 feed-forward expression loop drives pancreatic islet differentiation in the mouse (2009-11-30)Department: Cell and Developmental BiologyIn humans, the proper growth and homeostasis of endocrine islets in the pancreas is of great medical importance, in that loss and dysfunction of islet cells result in Type 1 and Type 2 Diabetes Mellitus. One of the major ...
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(2003-11-10)Department: Cell and Developmental BiologyCytokinetic actomyosin ring formation (CAR) in S. pombe requires two independent actin nucleation pathways, one dependent on the Arp2/3 complex and another involving the formin Cdc12p. Here we investigate the role of the ...
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(2012-03-15)Department: Cell and Developmental BiologyWound healing, an essential function to the survival of all multicellular organisms, requires the precise orchestration of multiple cell types in order to repair the damaged tissue. Wound healing involves three overlapping ...
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(2019-06-20)Department: Cell and Developmental BiologyCellular homeostasis, a fundamental requirement for all living organisms, is maintained in part through endocytic downregulation. Endocytosis of nutrient transporters is regulated in response to changing environmental ...
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(2013-11-08)Department: Cell and Developmental BiologyEvery organism experiences stress, which occurs when there is a perturbation of homeostasis. Individual cells experience stress throughout their physiological processes and have developed many mechanisms to cope with that ...
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(2008-12-29)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY THE ROLE OF α-ENDOSULFINE IN THE FEMALE MEIOTIC CELL CYCLE IN DROSOPHILA JESSICA R. VON STETINA Dissertation under the direction of Professor Daniela Drummond-Barbosa Meiosis is coupled ...
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(2010-03-02)Department: Cell and Developmental BiologyPathological ocular angiogenesis, or ocular neovascularization (NV) is a central feature of retinopathy of prematurity (ROP), proliferative diabetic retinopathy (PDR), and age-related macular degeneration (AMD). In the ...
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(2010-12-06)Department: Cell and Developmental BiologyAdult stem cells respond to environmental signals, such as diet, to properly maintain tissues; however, the mechanisms involved are largely unknown. The Drosophila ovary is a stem cell-based tissue that responds dramatically ...
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(2010-05-17)Department: Cell and Developmental BiologyTHE ROLE OF FOXM1 IN GROWTH FACTOR-MEDIATED PANCREATIC BETA-CELL PROLIFERATION JIA ZHANG Dissertation under the direction of Professor Maureen A. Gannon Both type I and type II diabetes are due to an either absolute ...
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(2006-12-04)Department: Cell and Developmental BiologySNAP-25 and syntaxin 4 are SNARE proteins that are involved in membrane transport. In order for proteins to traffic properly through membranous organelles, a series of budding and fusion events must occur between donor and ...
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(2015-03-20)Department: Cell and Developmental BiologyDiabetic retinopathy (DR) is one of the leading causes of vision loss in working age populations. Clinically, DR is divided into early non-proliferative diabetic retinopathy (NPDR), characterized by retinal vascular ...
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(2008-04-14)Department: Cell and Developmental BiologyRecovery from acute kidney injury (AKI) requires renal tubule cell regeneration. The population of cells that repair the damaged proximal tubule epithelial cells (PTC) has been proposed to be derived from an external ...
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(2004-12-01)Department: Cell and Developmental BiologyThe NF-kappaB pathway has been shown to play a critical role in both adaptive and innate immunity and has been implicated as a focal point for induction of lung inflammation by a variety of inflammatory stimuli; however, ...
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(2010-10-22)Department: Cell and Developmental BiologyThe docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the leading edge plasma ...