Browsing Electronic Theses and Dissertations by Department "Cancer Biology"
Now showing items 141-160 of 161
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(2009-11-24)Department: Cancer BiologyThe findings presented in this dissertation identify cytosolic phospholipase A2 (cPLA2) as a key component in tumor angiogenesis and the response of vascular endothelial cells to therapeutic doses of ionizing radiation ...
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(2015-07-09)Department: Cancer BiologyCANCER BIOLOGY The role of mTORC2 in mammary morphogenesis and HER2-mediated tumorigenesis Meghan Melinda Morrison Dissertation under the direction of Professor Rebecca Cook The phosphatidyl inositol-3-kinase (PI3K)/Akt ...
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(2011-10-03)Department: Cancer BiologyNuclear factor-êB (NF-êB) inducing kinase (NIK) is a MAP3K that regulates activation of NF-êB. NIK is often over-expressed in tumor cells, including melanoma, but the significance of this in melanoma progression remains ...
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(2016-03-31)Department: Cancer BiologyBenign prostatic hyperplasia (BPH) is a common, progressive chronic disease. Inflammation is associated with prostatic enlargement and resistance to 5?-reductase inhibitor (5ARI) therapy. Activation of the nuclear factor-kappa ...
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(2016-11-23)Department: Cancer BiologyDespite recent progress, non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality in the United States and new therapeutic approaches are needed. Nuclear factor κB (NF-κB) is a master regulator ...
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(2012-04-04)Department: Cancer BiologyCadherins and catenins are important regulators of tissue homeostasis and cancer. Here, we report critical roles for p120 catenin (p120) in mammary development and breast cancer. In the untransformed gland, p120 ablation ...
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(2011-03-29)Department: Cancer BiologyMyeloid derived suppressor cells (MDSCs) play an important role in cancer progression, and elucidating the mechanisms involved in the accumulation and function of these cells is important. Preliminary data indicated that ...
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(2018-05-21)Department: Cancer BiologyThe bone-tumor microenvironment is recognized as a dynamic place where critical cell interactions occur and play an important role in altering tumorigenesis. While many studies have investigated the effects of cellular ...
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(2010-09-09)Department: Cancer BiologyThe interactions between malignant plasma cells and the bone marrow microenvironment are critical for the development of multiple myeloma and the associated osteolytic bone disease. Only recently are studies beginning to ...
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(2015-07-14)Department: Cancer BiologyIntestinal homeostasis relies on complex interactions between the intestinal epithelium, microbiota, and host immune system, all of which cooperate to maintain homeostasis in an environment colonized and challenged by an ...
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(2008-03-06)Department: Cancer BiologyProstaglandin E2 (PGE2), which exerts its functions by binding to four G protein-coupled receptors (EP1-4), is implicated in tumorigenesis. Among the four EP receptors, EP3 is unique in that it exists as alternatively spliced ...
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(2016-08-12)Department: Cancer BiologyCANCER BIOLOGY The Role of Toll-Like Receptor 9 in Helicobacter pylori-Mediated Inflammation and Carcinogenesis Matthew Gordon Varga Dissertation under the direction of Dr. Richard M. Peek Jr., MD Helicobacter pylori ...
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(2012-12-07)Department: Cancer BiologyVAPB (VAMP-associated protein B) is an endoplasmic reticulum protein that regulates multiple biological functions. VAPB protein expression is elevated in human breast cancers and correlates with poor prognosis. Despite ...
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(2012-11-26)Department: Cancer BiologyTo improve our understanding of LZAP’s role in normal and cancer cell biology, the work in this thesis explored LZAP activities in development and carcinogenesis. This dissertation focused on understanding the role of LZAP ...
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(2009-08-11)Department: Cancer BiologyGenetic heterogeneity is a key factor involved in tumor progression, and it is increasingly recognized that heterogeneity of phenotypic traits exists among individual cancer cells. In this dissertation, I investigate the ...
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(2011-04-07)Department: Cancer BiologyCancer targeted imaging plays an important role in cancer diagnosis. It allows us to rapidly evaluate tumor responses to certain treatments. Peptide-based imaging probes have been widely used in cancer targeted imaging. ...
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(2008-04-14)Department: Cancer BiologyColon cancers arise as the consequence of the accumulation of mutations and epigenetic alterations in normal cells that lead to the transformation of these cells into cancer. One way through which these genetic and ...
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(2021-03-31)Department: Cancer BiologyThe Wnt/b-catenin (canonical) signaling pathway is an evolutionarily conserved pathway that is critical for normal development, and misregulation of Wnt signaling can lead to diseases in humans. Many components of the Wnt ...
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(2018-11-16)Department: Cancer BiologyThe study of oncogenic tyrosine kinase fusions began with the discovery of the t(9:22) translocation in chronic myelogenous leukemia and its chimeric protein product, BCR-ABL. Since then, chromosomal rearrangements resulting ...
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(2024-03-25)Department: Cancer BiologyClear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling and a tumor microenvironment (TME) highly enriched in myeloid and lymphoid cells. Loss of the von Hippel Lindau (VHL) gene is a ...