The role of Rgs2 in hematopoiesis and myeloid derived suppressor cells in cancer

Abstract

Myeloid derived suppressor cells (MDSCs) play an important role in cancer progression, and elucidating the mechanisms involved in the accumulation and function of these cells is important. Preliminary data indicated that Rgs2 may have a role in MDSC production and differentiation. As such, its role in hematopoiesis and myeloid cell differentiation was examined. Overall, hematopoiesis was not affected by loss of Rgs2, and MDSC production and heterogeneity in the spleen were not altered. However, Rgs2 deficiency in MDSCs abrogated the tumor promoting roles of these cells, accompanied by drastically decreased MCP-1 production, and subsequent effects on endothelial cells and leukocytes. Together, these data suggest that Rgs2 affects the tumor promoting functions of MDSCs through mediating MCP-1 production. In targeting the signaling pathway involving Rgs2 in MDSCs, we may be able to promote an anti-tumor response to cancer, enhancing patient outcome.