Browsing Electronic Theses and Dissertations by Department "Cell and Developmental Biology"
Now showing items 121-140 of 179
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(2008-03-19)Department: Cell and Developmental BiologyNaked family members (Drosophila Naked Cuticle and mammalian Naked1 and Naked2) have been identified as inducible antagonists of canonical Wnt signaling. We previously reported that Naked2, but not Naked1, interacts with ...
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(2018-02-19)Department: Cell and Developmental BiologyProper cell division to yield two daughter cells with identical complements of genomic material requires coordination between mitosis and cytokinesis. In the event of a mitotic error, checkpoint mechanisms must inhibit ...
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(2019-09-09)Department: Cell and Developmental BiologyThe WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...
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(2017-03-27)Department: Cell and Developmental BiologyThe Wnt pathway is a highly-conserved pathway that controls many developmental processes and is mutated in many human diseases (e.g., cancer). The tumor suppressor adenomatous polyposis coli (APC) is a critical negative ...
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(2007-12-13)Department: Cell and Developmental BiologyDissertation under the direction of Professor David M. Miller III Impairment of neurons expressing the neurotransmitter ?-amminobutyric acid (GABA) can result in psychiatric diseases as diverse as schizophrenia, epilepsy, ...
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(2010-04-05)Department: Cell and Developmental BiologyThe Wnt/beta-catenin signaling pathway is a well-conserved signal transduction pathway that is highly regulated during metazoan development and is associated with various human diseases. In the current model of Wnt/beta-catenin ...
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(2015-03-11)Department: Cell and Developmental BiologyThe nuclear envelope (NE) and endoplasmic reticulum (ER) are components of the same contiguous membrane system with distinct functions. Mounting evidence indicates that some ER proteins have roles in nuclear pore complex ...
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(2018-09-20)Department: Cell and Developmental BiologyInterstrand DNA cross-links (ICLs) block both replication and transcription, and are commonly repaired by the Fanconi anemia (FA) pathway. However, FA-independent repair mechanisms of ICLs remain poorly understood. Yeast ...
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(2018-07-11)Department: Cell and Developmental BiologyThe DNA damage response consists of complex signaling pathways that act to recognize and remove various types of genomic insults. One particularly dangerous type of lesion is an interstrand cross-link (ICL). ICLs are ...
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(2013-02-19)Department: Cell and Developmental BiologySonic hedgehog (Shh), a secreted signaling molecule, is generated from the posterior limb margin and essential in regulating anterior-posterior (A-P) patterning as well as growth and differentiation of limb mesenchyme. ...
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(2019-03-22)Department: Cell and Developmental BiologyInflammatory Bowel Disease (IBD) and its subtype Crohn’s disease (CD) arise due to a loss of tolerance to environmental antigens in genetically susceptible individuals. Longitudinal analysis of CD incidence has identified ...
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(2010-05-17)Department: Cell and Developmental BiologySonic hedgehog (Shh) signaling regulates important biological processes during embryogenesis and adult homeostasis. Deregulation of this essential signaling pathway can lead to congenital defects and tumorigenesis. In this ...
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(2013-09-23)Department: Cell and Developmental BiologyThe spliceosome is a dynamic macromolecular machine that catalyzes the removal of introns from pre-mRNA, yielding mature message. Schizosaccharomyces pombe Cwf10 (homolog of Saccharomyces cerevisiae Snu114 and human U5-116K), ...
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(2015-07-07)Department: Cell and Developmental BiologyHeritable Pulmonary Arterial Hypertension (HPAH) is a rare, fatal disease of the pulmonary vasculature for which there is no cure. The majority of HPAH patients inherit mutations in the BMP type 2-receptor gene, BMPR2, but ...
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(2018-04-02)Department: Cell and Developmental BiologyPost-translational modification of proteins are events involved in many cellular processes, including the cell cycle. During mitosis, the metaphase to anaphase transition is regulated by the ubiquitin ligase activity of ...
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(2017-03-21)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY Structural Analysis of the Helicobacter pylori toxin VacA Tasia Marie Pyburn Dissertation under the direction of Associate Professor Melanie Ohi Helicobacter pylori is a Gram-negative bacterium ...
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(2008-06-27)Department: Cell and Developmental BiologyThis project aims to better understand the role of Src kinase on the development of colon cancer. Enhanced Src expression and activity are commonly elevated in colon cancer, with progressively higher activity observed as ...
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(2014-06-24)Department: Cell and Developmental BiologyA developing vertebrate embryo can only subsist for a finite time without a vasculature. The vascular system is one of the earliest organ systems to develop and allows continued rapid maturation of complex multicellular ...
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(2012-01-26)Department: Cell and Developmental BiologyEpicardial development is a complex process that involves tightly regulated coordination of concurrent cellular behaviors ranging from sheet migration to secretion. The regulation of these behaviors is poorly understood, ...
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(2017-03-31)Department: Cell and Developmental BiologyBoth type I and type II diabetes are related to β-cell defects in the pancreatic islet of Langerhans. Deriving β-cells from stem cells and other mature cell types provides an important cell source for transplantation-based ...