Browsing Electronic Theses and Dissertations by Department "Pharmacology"
Now showing items 101-120 of 143
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(2010-02-02)Department: PharmacologyCalcium/calmodulin-dependent protein kinase IV (CaMKIV) is a serine/threonine kinase that plays a crucial role in the control of synaptic plasticity and T cell maturation. Activation of CaMKIV requires Ca2+/calmodulin ...
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(2006-11-27)Department: PharmacologyThe transient receptor potential (TRP) ion channels are implicated in diverse physiological processes, however their regulatory mechanisms remain obscure. In Drosophila, TRP is a calcium channel mediating the light-dependent ...
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(2017-02-22)Department: PharmacologyThe dopamine (DA) transporter (DAT) is a presynaptic membrane protein that regulates dopaminergic neurotransmission by controlling DA levels at the synapse via active reuptake. The DAT is also capable of engaging in reverse ...
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(2020-04-21)Department: PharmacologyThe A2a-adrenergic receptor (A2a-AR) agonist guanfacine has been investigated as a potential treatment for substance use disorders. While decreasing stress-induced reinstatement of cocaine seeking in animal models and ...
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(2012-12-12)Department: PharmacologyHypertension is a prevalent disease affecting one in three adults in the United States. Approximately 25 % of the adult population is either not receiving therapy for their hypertension or is unable to control their blood ...
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(2015-11-27)Department: PharmacologyPost-Traumatic Stress Disorder (PTSD) is characterized by persistent stress responses after experiencing a traumatic event. Hyperarousal and accompanying sleep disruptions, such as insomnia and nightmares, are among the ...
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(2023-02-24)Department: PharmacologyDegeneration of the cholinergic basal forebrain is implicated in cognitive deficits and sleep/wake architecture disturbances in non-pathological aging and Alzheimer's Disease (AD). The acetylcholinesterase inhibitors ...
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(2019-09-05)Department: PharmacologyVision loss during glaucoma results from degeneration of retinal ganglion cell (RGC) axons. Glaucoma produces deficits in axon transport in RGCs prior to structural degeneration, representing a potential therapeutic window ...
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(2008-12-06)Department: PharmacologyElectrical signaling events are required for each human thought, feeling, and perception, the movement of our limbs, and the beat of our hearts. As the initiators of action potentials in excitable tissues, voltage-gated ...
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(2019-03-25)Department: PharmacologyThe antidepressant-sensitive serotonin (5-HT) transporter (Slc6a4; SERT) is a dynamically regulated membrane protein that tightly controls the signaling potential of 5-HT by rapidly clearing 5-HT from the extracellular ...
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(2020-05-19)Department: PharmacologyMammalian cells respond to environmental stimuli by transforming the presence of a novel chemical into actionable biological processes via receptors located both internally and at the cell surface. Nuclear receptors are ...
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(2012-11-21)Department: PharmacologyProstaglandin E2 (PGE2) is a lipid autacoid, which is an oxidative metabolite of arachidonic acid synthesized by cyclooxygenase and prostaglandin E synthases. PGE2 is proposed to mediate in part the pathophysiology of ...
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(2010-07-16)Department: PharmacologyMarijuana is the most commonly used illicit drug, and its major active component, Δ9-tetrahydrocannabinol (Δ9-THC) exert its functions by targeting cannabinoid receptors, CNR1 and CNR2. There receptors are also targeted ...
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(2014-11-06)Department: PharmacologyPhospholipase D (PLD) catalyzes the production of the lipid second messenger phosphatidic acid (PtdOH). PLD expression and/or enzymatic activity are both elevated in a variety of human cancers. Inhibition of PLD enzymatic ...
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(2015-11-24)Department: PharmacologyMalignant cancers are the second leading cause of death in the United States, with a projected 1.6 million new diagnoses per year and almost 600,000 deaths. Our understanding of the molecular pathways causing tumor initiation, ...
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(2023-06-05)Department: PharmacologyInflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
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(2023-06-05)Department: PharmacologyInflammation and oxidative stress are linked to the pathogenesis of atrial fibrillation (AF). Reactive dicarbonyls generated by lipid peroxidation represent a major component of oxidative injury, but their role in ...
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(2010-12-10)Department: PharmacologyThe goal of my thesis research is to elucidate the catalytic mechanism and physiological function of the atypical mammalian lipoxygenase, epidermal lipoxygenase-3. Although named as a lipoxygenase based on sequence homology ...
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(2016-04-08)Department: PharmacologyGi/o-coupled G-protein coupled receptors (GPCRs) can exert an inhibitory effect on vesicle release through several G-protein driven mechanisms, more than one of which may be concurrently present in individual presynaptic ...
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(2021-12-21)Department: PharmacologySevere injury is a leading cause of death and disability worldwide, affecting over 3 million individuals in the U.S. yearly. Early complications of severe injury include bleeding, thrombosis and organ dysfunction, and if ...