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A novel knowledge based conformation sampling algorithm and applications in drug discovery
(2016-08-12)
Computational approaches have become important tools in drug discovery. Computational technologies have been developed for application in all aspects of the drug discovery process including target identification, lead ...
Structural Consequences of the C8-Guanine DNA Adduct Formed by 3-Nitrobenzanthrone; an Environmental Carcinogen
(2016-08-03)
Damage to DNA results from many endogenous and exogenous sources and plays a significant role in cancer etiology. 3-Nitrobenzathrone (3-NBA) is a component of diesel exhaust that is known to form DNA adducts. Aminobenzanthrone ...
Stigma, Access to Care, and Sexual Minority Women's Health
(2016-08-05)
Sexual minority women experience a number of physical and mental health disparities compared to their heterosexual peers. This three-paper dissertation addresses the ways in which stigma and access to care explain outcomes ...
Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells
(2016-10-03)
MOLECULAR PHYSIOLOGY & BIOPHYSICS
Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells
Kayla Boortz
Dissertation under the direction of Professor Richard O’Brien, Ph.D.
G6PC2 encodes an islet-specific ...
Interactions between Angiotensin II and Prostaglandin E2: Mechanisms for Regulation of Vascular Reactivity
(2016-08-05)
Prostaglandin E2 (PGE2), a cyclooxygenase metabolite that generally acts as a systemic vasodepressor, has been shown to have vasopressor effects under certain physiologic conditions. Previous studies have demonstrated that ...
Omicron: a Galaxy for reproducible proteogenomics
(2016-08-05)
Proteomics allows us to see post-translational modifications and expression patterns that we cannot see with genomics and transcriptomics alone. By itself, proteomics has limited sensitivity to detect genetic variation ...
Improving image-guided preoperative planning in deep brain stimulation procedures
(2016-11-14)
Deep brain stimulation is a stereotactic surgery widely used to treat neurological disorders such as Parkinson’s disease. This procedure involves inserting a permanent electrode into the deep brain and sending electrical ...
The Role of Toll-Like Receptor 9 in Helicobacter pylori-Mediated Inflammation and Carcinogenesis
(2016-08-12)
CANCER BIOLOGY
The Role of Toll-Like Receptor 9 in Helicobacter pylori-Mediated
Inflammation and Carcinogenesis
Matthew Gordon Varga
Dissertation under the direction of Dr. Richard M. Peek Jr., MD
Helicobacter pylori ...
Electrical stimulation to promote selective reinnervation of denervated laryngeal muscles
(2016-08-11)
Vocal fold paralysis (VFP) that results from injury to motor axons in the recurrent laryngeal nerve (RLN) is a common clinical problem. In the majority of these patients, misdirected regeneration of neural fibers in the ...
The Role of Transcription Factor Krüppel-like Factor 2 in Lymphocyte Migration and Homeostasis
(2016-08-18)
The immune system is charged with the task of protecting the body from pathogens and clearing apoptotic or cancerous cells to prevent chronic disease. Controlled cell migration shapes lymphocyte subset development, ...