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Now showing items 11-20 of 416
Mechanobiology of Cardiac Disease and Fibrosis: a Novel Role for Cadherin-11
(2016-11-22)
Heart disease is a leading cause of death worldwide, and many cardiac conditions that contribute to high morbidity and mortality are characterized by tissue fibrosis and maladaptive remodeling. Build-up of extracellular ...
Calcium and Magnesium in Relation to Colorectal Neoplasia, Lipid Profile and Uric Acid
(2016-11-22)
It is plausible that calcium intake and the calcium: magnesium (Ca:Mg) intake ratio play an essential role in the development of colorectal cancer. The first project of this dissertation was to determine the role of calcium ...
Exploring Zwitterionic Coronas as Alternatives to Traditional PEG Architectures for Improved siRNA Polyplex Pharmacokinetics and Tumor Delivery
(2016-11-21)
Although siRNA-based therapeutics hold great promise for systemic cancer treatment, polyplex nanocarrier systems face many intravenous challenges that limit their pharmacokinetic potential and therefore reduce tumor ...
Development and application of ligand-based computational methods for de-novo drug design and virtual screening
(2016-11-18)
Ligand-based computational drug discovery (LB-CADD) methods have been used widely over the last several decades to aid medicinal chemistry campaigns via virtual high-throughput screening (vHTS) and de-novo molecular design. ...
"The Hebrew will turn Christian; he grows kind": Reimagining Community in Shakespeare's The Merchant of Venice
(2016-11-28)
In light of the effluence of Islamophobia, targeted violence against black peoples, and hate speech against the Other monopolizing contemporary US political rhetoric, Shakespeare’s The Merchant of Venice seems disturbingly ...
Inter- and Intrapersonal Body Perception in Schizophrenia
(2016-11-22)
Individuals with schizophrenia consistently display social functioning deficits with underlying emotion recognition impairments. Simulation of other’s emotional expressions facilitates recognition. Emotional states are ...
“We’re all caught up in it one way or another”: African American Comics, Civil Rights, and Political Personhood
(2016-11-30)
One of the main goals of Jim Crow segregation laws—apart from demarcating a clear societal boundary between the races—was to exclude African Americans from the benefits, promises and ideals of American nationhood and ...
Sensory Signs: Perception and Passion in Eliza Haywood's Fantomina
(2016-11-28)
This paper argues that Eliza Haywood’s Fantomina inverts the sensory thought experiment known as the Molyneux problem. Haywood establishes a clear distinction between different types of sensory perception in Fantomina and ...
Probing Cell Signaling Networks in Microfluidic Devices
(2016-11-18)
Detection of signals is critical for the function of eukaryotic cells. D. discoideum cells are particularly adept at responding chemical gradients, sensing single percent concentration changes across their body. We measure ...
Single-Event Characterization of Flip-Flops after Total Ionizing Dose Exposures for a 20-nm Bulk, Planar Technology
(2016-11-30)
This paper looks at single-event upset characterization of flip flops across total ionizing dose (TID) exposures and annealing current for a 20-nm bulk, planar, CMOS technology. 20-nm chips were irradiated to five different ...