Browsing Research reports by Title

Now showing items 2-13 of 13

    • Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis 
      Linton, MacRae F.; Moslehi, Javid J.; Babaev, Vladimir R. (International Journal of Moledular Sciences, 2019-06-01)
      The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
    • The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10 
      Paulson, Carolyn N.; John, Kristen; Baxley, Ryan M.; Kurniawan, Fredy; Orellana, Kayo; Francis, Rawle; Sobeck, Alexandra; Eichman, Brandt F.; Chazin, Walter J.; Aihara, Hideki; Georg, Gunda I.; Hawkinson, Jon E.; Bielinsky, Anja-Katrin (Open Biology, 2019-08)
      Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor ...
    • Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation 
      Leonard, Alan C.; Rao, Prassanna; Kadam, Rohit P.; Grimwade, Julia E. (Frontiers in Microbiology, 2019-08-29)
      Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome. Orisomes perform two ...
    • Dual roles for the ER Membrane Protein Complex in Flavivirus Infection: Viral Entry and Protein Biogenesis 
      Barrows, Nicholas J.; Anglero-Rodriguez, Yesseinia; Kim, Byungil; Jamison, Sharon F.; Le Sommer, Caroline; McGee, Charles E.; Pearson, James L.; Dimopoulos, George; Ascano, Manuel; Bradrick, Shelton S.; Garcia-Blanco, Mariano A. (SCIENTIFIC REPORTS, 2019-07-04)
      Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue ...
    • FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients 
      Guengerich, F. Peter (Food and Chemical Toxicology, 2020-01)
      In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This ...
    • FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients 
      Cohen, Samuel M.; Eisenbrand, Gerhard; Fukushima, Shoji; Gooderham, Nigel J.; Guengerich, F. Peter; Hecht, Stephen S.; Rietjens, Ivonne M. C. M.; Bastaki, Maria; Davidsen, Jeanne M.; Harman, Christie L.; McGowen, Margaret M.; Taylor, Sean, V. (Food and Chemical Toxicology, 2020-01)
      In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. NFC flavor materials ...
    • Imaging Cataract-Specific Peptides in Human Lenses 
      Schey, Kevin L.; Wang, Zhen; Rose, Kristie L.; Anderson, David M. G. (Cells, 2023-01-13)
      Age-related protein truncation is a common process in long-lived proteins such as proteins found in the ocular lens. Major truncation products have been reported for soluble and membrane proteins of the lens, including ...
    • Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells 
      Albertolle, Matthew E.; Glass, Sarah M.; Trefts, Elijah; Guengerich, F. Peter (Journal of Biological Chemistry, 2019-04-19)
      Oxidative modifications of cysteine residues are an important component in signaling pathways, enzymatic regulation, and redox homeostasis. Current direct and indirect methods detect specific modifications and a general ...
    • p73 regulates epidermal wound healing and induced keratinocyte programming 
      Beeler, J. Scott; Marshall, Clayton B.; Gonzalez-Ericsson, Paula I.; Shaver, Timothy M.; Guasch, Gabriela L. Santos; Lea, Spencer T.; Johnson, Kimberly N.; Jin, Hailing; Venters, Bryan J.; Sanders, Melinda E.; Pietenpol, Jennifer A. (Plos One, 2019-06-19)
      p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal ...
    • Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection 
      Bensing, Barbara A.; Li, Liang; Yakovenko, Olga; Wong, Maurice; Barnard, Karen N.; Iverson, T. M.; Lebrilla, Carlito B.; Parrish, Colin R.; Thomas, Wendy E.; Xiong, Yan; Sullam, Paul M. (PLOS Pathogens, 2019-06)
      Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal ...
    • The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding 
      Indurthi, Venkata S. K.; Jensen, Jaime L.; Leclerc, Estelle; Sinha, Sangita; Colbert, Christopher L.; Vetter, Stefan W. (Bioscence Reports, 2020-01-30)
      The receptor for advanced glycation end products (RAGE) recognizes damage-associated molecular patterns (DAMPs) and plays a critical role for the innate immune response and sterile tissue inflammation. RAGE overexpression ...
    • Value-driven attentional capture enhances distractor representations in early visual cortex 
      Itthipuripat, Sirawaj; Sprague, Thomas C.; Serences, John T. (PLOS Biology, 2019-08)
      When a behaviorally relevant stimulus has been previously associated with reward, behavioral responses are faster and more accurate compared to equally relevant but less valuable stimuli. Conversely, task-irrelevant stimuli ...