Biochemistry explores the chemistry that underpins all biological processes. Building on research advances, Biochemistry uses a variety of tools and approaches to open up new frontiers and address field-bending issues of biological significance with ever-increasing accuracy and detail.

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  • Paulson, Carolyn N.; John, Kristen; Baxley, Ryan M.; Kurniawan, Fredy; Orellana, Kayo; Francis, Rawle; Sobeck, Alexandra; Eichman, Brandt F.; Chazin, Walter J.; Aihara, Hideki; Georg, Gunda I.; Hawkinson, Jon E.; Bielinsky, Anja-Katrin (Open Biology, 2019-08)
    Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor ...
  • Itthipuripat, Sirawaj; Sprague, Thomas C.; Serences, John T. (PLOS Biology, 2019-08)
    When a behaviorally relevant stimulus has been previously associated with reward, behavioral responses are faster and more accurate compared to equally relevant but less valuable stimuli. Conversely, task-irrelevant stimuli ...
  • Bensing, Barbara A.; Li, Liang; Yakovenko, Olga; Wong, Maurice; Barnard, Karen N.; Iverson, T. M.; Lebrilla, Carlito B.; Parrish, Colin R.; Thomas, Wendy E.; Xiong, Yan; Sullam, Paul M. (PLOS Pathogens, 2019-06)
    Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal ...
  • Leonard, Alan C.; Rao, Prassanna; Kadam, Rohit P.; Grimwade, Julia E. (Frontiers in Microbiology, 2019-08-29)
    Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome. Orisomes perform two ...
  • Beeler, J. Scott; Marshall, Clayton B.; Gonzalez-Ericsson, Paula I.; Shaver, Timothy M.; Guasch, Gabriela L. Santos; Lea, Spencer T.; Johnson, Kimberly N.; Jin, Hailing; Venters, Bryan J.; Sanders, Melinda E.; Pietenpol, Jennifer A. (Plos One, 2019-06-19)
    p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal ...
  • Albertolle, Matthew E.; Glass, Sarah M.; Trefts, Elijah; Guengerich, F. Peter (Journal of Biological Chemistry, 2019-04-19)
    Oxidative modifications of cysteine residues are an important component in signaling pathways, enzymatic regulation, and redox homeostasis. Current direct and indirect methods detect specific modifications and a general ...
  • Linton, MacRae F.; Moslehi, Javid J.; Babaev, Vladimir R. (International Journal of Moledular Sciences, 2019-06-01)
    The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
  • Barrows, Nicholas J.; Anglero-Rodriguez, Yesseinia; Kim, Byungil; Jamison, Sharon F.; Le Sommer, Caroline; McGee, Charles E.; Pearson, James L.; Dimopoulos, George; Ascano, Manuel; Bradrick, Shelton S.; Garcia-Blanco, Mariano A. (SCIENTIFIC REPORTS, 2019-07-04)
    Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue ...