Now showing items 1-5 of 5

    • Albertolle, Matthew E.; Glass, Sarah M.; Trefts, Elijah; Guengerich, F. Peter (Journal of Biological Chemistry, 2019-04-19)
      Oxidative modifications of cysteine residues are an important component in signaling pathways, enzymatic regulation, and redox homeostasis. Current direct and indirect methods detect specific modifications and a general ...
    • Linton, MacRae F.; Moslehi, Javid J.; Babaev, Vladimir R. (International Journal of Moledular Sciences, 2019-06-01)
      The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
    • Beeler, J. Scott; Marshall, Clayton B.; Gonzalez-Ericsson, Paula I.; Shaver, Timothy M.; Guasch, Gabriela L. Santos; Lea, Spencer T.; Johnson, Kimberly N.; Jin, Hailing; Venters, Bryan J.; Sanders, Melinda E.; Pietenpol, Jennifer A. (Plos One, 2019-06-19)
      p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal ...
    • Barrows, Nicholas J.; Anglero-Rodriguez, Yesseinia; Kim, Byungil; Jamison, Sharon F.; Le Sommer, Caroline; McGee, Charles E.; Pearson, James L.; Dimopoulos, George; Ascano, Manuel; Bradrick, Shelton S.; Garcia-Blanco, Mariano A. (SCIENTIFIC REPORTS, 2019-07-04)
      Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue ...
    • Leonard, Alan C.; Rao, Prassanna; Kadam, Rohit P.; Grimwade, Julia E. (Frontiers in Microbiology, 2019-08-29)
      Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome. Orisomes perform two ...