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Informatics for High-Throughput and Distributed Analysis of Medical Images
(2011-12-22)
Clinical research with medical imaging typically involves large-scale data analysis with interdependent software toolsets tied together in a processing workflow. Grid queuing software has become more advanced to meet the ...
Trajectory Auto-Corrected Image Reconstruction
(2015-11-20)
The goal of this research is to develop image reconstruction techniques to automatically correct for errors in Magnetic Resonance Imaging (MRI) data due to errors in the trajectory used in the data acquisition. A method ...
A comparison of individual and population-derived vascular input functions for quantitative DCE-MRI in rats
(2012-12-07)
Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is a method that can be used to quantitatively and qualitatively assess physiological characteristics of tissue. Quantitative DCE-MRI requires an estimate of ...
Dynamic B0 shimming at 7 Tesla
(2010-12-06)
Increased main field (B0) strength in MRI leads to increased signal levels but also causes higher field inhomogeneity (delta-B0). This thesis presents the implementation and evaluation of ‘Dynamic Shimming’, an advanced ...
Studies Of Proton Nuclear Magnetic Resonance Relaxation In Human Cortical Bone: From Ex Vivo Spectroscopy To Clinical Imaging Methods
(2011-11-23)
Current clinical bone diagnostic measures rely predominantly on X-ray-based contrast and are primarily sensitive to bone mineral content. Since bone also contains collagen and water components, which are heavily implicated ...
The Information Content of mcDESPOT
(2011-12-12)
A statistical analysis of the magnetic resonance imaging-based mcDESPOT method for characterizing two exchanging water proton pools--a seven-dimensional problem that fits to multiple flip angle measurements of both spoiled ...
SENSE & Susceptibility: Respiration-Related Susceptibility Effects and their Interactions with Parallel Imaging
(2006-12-06)
Most functional MRI studies rely on fast Echo Planar Imaging, which is sensitive to magnetic susceptibility effects. These effects can lead to image-to-image signal instability, reducing the reliability of functional ...
Optimization, Application, and Cross-correlation of DCE-MRI in Small Animal Models of Cancer
(2010-11-19)
With cancer encompassing a range of disease states and phenotypes, assessing treatment efficacy early, accurately, and non-invasively is essential to optimize therapy planning on an individualized basis. This work discusses ...
Harnessing Non-invasive Imaging and Modeling towards Early Detection of Tumor Resistance to Targeted Therapy
(2017-02-03)
Clinical imaging and biopsies are major tools for cancer diagnosis. We explore whether serial imaging coupled with a mathematical model could test and refine patient specific forecasts for therapy outcomes.
We first ...
Imaging and Genetics of Two Amyloid Related Diseases: Alzheimer’s Disease and Down Syndrome
(2014-02-20)
Alzheimer’s Disease is an irreversible, degenerative disease of the brain that accounts for a majority of dementia cases each year, in both the general population and in patients with Down Syndrome. The advancement of in ...