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Development of Decision Support Tools for Water Energy Food Infrastructure Management of Sri Lanka
(2020-01-17)
The energy and food sectors of the economy heavily rely on water resources. All nations face challenges of meeting increasing demand for water, food, and energy due to limited and uncertain resources, complex multisector ...
Mechanistic Hypothesis Exploration of Signaling Network Processes via Bayesian Inference Methods
(2020-01-15)
Characterization of signal execution dynamics within complex biochemical networks is highly challenging but necessary to understand how cells process signals and commit to a biological phenotype. Mechanistic interpretation ...
Elucidating the Membrane Diffusion Dynamics of Muscarinic-1 Acetylcholine Receptors with Quantum Dots
(2020-01-24)
To investigate this dynamic response at the level of individual molecular species, human embryonic kidney (HEK)-293 cells were stably transfected with hemagglutinin (HA)-tagged human muscarinic-1 acetylcholine receptors ...
Simulation of Optical Energy Deposition for Pulsed Laser-Induced Single Event Effects Testing in Microelectronic Devices
(2020-01-30)
Pulsed laser-induced charge injection is a popular experimental technique for investigation of single event effects in microelectronic devices. Unlike traditional heavy ion testing, which is costly and limited to a relatively ...
KRAS-dependent Extracellular Vesicles in Colorectal Cancer: Cargo, Biogenesis, and Function
(2020-01-02)
Colorectal cancer (CRC) cells release protein-laden extracellular vesicles (EVs) that can alter the tumor microenvironment and spread drug resistance. I compared long RNAs of cells and matched EVs from isogenic CRC cell ...
Adolescents’ Coping Socialization: The Interactive Role of Maternal Coping Suggestions and Adolescents’ Coping in Predicting Symptoms of Anxiety and Depression
(2020-01-02)
Adolescence is a developmental period characterized by increased exposure to stress in several life domains and a concomitant increase in risk for several types of internalizing and externalizing problems. Of particular ...
Heme Homeostasis and Utilization in Clostridioides difficle Pathogenesis and Persistence
(2020-01-14)
Invading microbial pathogens must sense and respond to the hostile environment of the vertebrate host to survive and cause infection. Clostridioides difficile, formerly Clostridium difficile, is the leading cause of ...
Uncertainty Quantification and Management in Additive Manufacturing
(2020-01-14)
Additive manufacturing (AM) has shown immense potential in several industries. However, significant variability in the product quality currently hinders widespread use of AM. The focus of this dissertation is on uncertainty ...
Developing and Evaluating Mappings of ICD-10 and ICD-10-CM Codes to Phecodes
(2020-01-17)
The phecode system was built upon the ICD-9-CM for PheWAS using the EHR. In this study, we developed and performed an initial evaluation of maps from ICD-10 and the ICD-10-CM codes to phecodes. We mapped ICD-10 and ICD-10-CM ...
Low-Performing Schools and School Reform: Three Essays on School Turnaround, the Mechanisms of Low Performance, and Leadership for Reform
(2020-06-15)
While federal education policy requires that states support their lowest performing schools, the research on how to effectively turn around these schools is limited. Drawing from 13 years of statewide administrative data ...