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Development of an Intraoperative Imaging Tool for Thyroid and Parathyroid Surgical Guidance
(2021-05-11)
Loss of parathyroid function (hypoparathyroidism) is an unintended consequence of endocrine neck surgeries. This leads to an inability of the patient to maintain healthy levels of blood calcium, as the parathyroid glands ...
Enabling Technologies for Image-Guided Interventions with Minimally Invasive Surgical Robots
(2021-05-07)
The desire to marry surgical robotics with surgical image guidance can be seen as a natural response to the limitations imposed by minimally invasive surgery. Compared to the human hand, surgical robots can offer reduced ...
ELAV(L1)ating Insight into Dynamic mRNA-Protein Interactions in Innate Immunity
(2021-05-10)
Upon pathogen detection, the innate immune system triggers signaling events leading to upregulation of pro-inflammatory and anti-microbial mRNA transcripts. RNA-binding proteins (RBPs) interact with these critical mRNAs ...
Synthetic Studies on Bielschowskysin
(2021-05-05)
Natural products have a long history of serving as therapeutic leads (e.g. taxol and compactin) and biological tools (e.g. rapamycin and oligomycin). Bielschowskysin is a rare and structurally complex marine diterpene, ...
Fossils, Literature, and the Origins of Race in the Americas: Museum Writing and the Poetics of Display
(2021-05-04)
This dissertation examines the presence of fossils in nineteenth-century literature of the
Americas. It argues that human and nonhuman ancient bones are more accurately understood if analyzed at the intersection of museum, ...
Porous silicon optical biosensors towards point-of-care applications
(2021-05-17)
Optical biosensors are devices that employ light to detect the presence or concentration of a biological analyte. These devices play an important role in modern society in areas that include medical diagnostics, infectious ...
Identification of CUL9-related signaling pathways in human pluripotent stem cells and cortical precursors
(2021-05-13)
The body of work presented in this dissertation details the characterization of a novel human-cell derived model of the understudied, non-canonical cullin scaffold CUL9. Unlike other cullins, previous efforts to characterize ...
High-Voltage-Stress Induced Degradation and Radiation Response of GaN-Based HEMTs
(2021-05-18)
GaN-based HEMTs are increasingly popular for use in space-based, high-power, high-voltage and high temperature applications due to the large band gap, high breakdown electric field, low carrier generation rate by thermal ...
Design of a Benchtop Facility for Parametric Evaluation of Engine Oil Quality
(2021-05-11)
Engine health monitoring is an emerging technology with economic and environmental benefits in automotive, marine, and industrial diesel engines applications. Engine oil quality is a strong marker of engine health and ...
Two-Dimentional Materials and their Biomedical Applications
(2021-05-18)
Two-dimensional (2D) materials, from graphene to transition metal dichalcogenides (TMDCs), have attracted tremendous attention from researchers in various fields owing to their exceptional properties. This dissertation ...