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Expression and role of long non-coding RNA H19 in aortic valve development and disease
(2020-01-16)
Aortic valve disease, including developmental defects and late-stage fibrocalcific remodeling, is a major global health burden. There is no pharmaceutical treatment for valve disease, and options for valve replacement are ...
An analysis of basement membrane repair in vivo
(2020-01-17)
Basement membranes are sheet-like extracellular matrixes that can be found on the basal surface of epithelial and endothelial cells, surrounding muscles and other organs, and in association with neurons. In addition to ...
Multidimensional Separations in Complex Biological Matrices Utilizing Chromatography, Ion Mobility, and Mass Spectrometry
(2021-03-23)
Mass spectrometry (MS) has been a rapidly growing analytical technique, especially when analyzing complex biological matrices in metabolomics, clinical applications, anti-doping applications, and routine testing analyses. ...
MULTIMODAL IMAGING UTILIZING MALDI IMS, IF, AUTOFLUORESCENCE, AND HISTOLOGICAL STAINING FOR THE INVESTIGATION OF LIPIDS INTEGRAL TO THE ADAPTIVE IMMUNE RESPONSE
(2021-03-23)
Adaptive immunity, the specified, targeted response of the immune system to pathogens or mutated cells, is integral to survival of many organisms. The malfunction of the adaptive immunity response in humans results in many ...
Improving Automated Quantification of MS Injuries with Deep Learning
(2021-03-24)
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system which affects nearly 1 million people in the US. Magnetic resonance imaging (MRI), as the most sensitive non-invasive technique, is used to ...
“Skirting” Society: How Women in Late Antique Persia Used Religious Pluralism to Subvert Gender Boundaries
(2021-03-23)
Late Antique Persia from the 3rd through 9th century AD was a center of religious plurality and change. Persia was a thriving center of a number of religions such as Zoroastrianism, Judaism, Christianity, and, after the ...
Characterizing the Effect of Lower Limb Dominance on Foot Kinematics During Walking
(2021-03-25)
Functional differences are exhibited by the dominant and non-dominant lower limbs during overtly asymmetric bilateral tasks (e.g., kicking a soccer ball). However, current biomechanical analyses of human locomotion typically ...
Integration between the mosquito immune and circulatory systems: from genetic mechanisms to evolutionary conservation
(2021-05-17)
The immune and circulatory systems are functionally integrated in the African malaria mosquito, Anopheles gambiae. This functional integration is exemplified by a subpopulation of hemocytes called periostial hemocytes that ...
A Quiet Revolution: Medicine, Intersex Activism, and the Politics of Consensus
(2021-05-12)
Over the past few decades, multiple actors, including clinicians, researchers, activists, intersex adults, and parents of intersex children, have engaged in debates over what intersex is and how—or whether—it should be ...
The Impact of Trauma and Early Life Adversity on Neural Structural Alterations during Development
(2021-05-06)
Childhood maltreatment is associated with various adverse outcomes in later stages of life including non-specific forms of psychopathology, deteriorated physical health, and poor psychosocial functioning. The developing ...