Browsing Electronic Theses and Dissertations by Subject "x-ray crystallography"
Now showing items 1-5 of 5
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(2016-07-29)Department: Microbiology and ImmunologySeasonal influenza remains a worldwide health concern and recently, the novel avian influenza virus, H5N1, has infected and caused disease in humans, though the virus is not currently capable of human-to-human transmission. ...
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Characterization of SRAP Domain DNA-Protein Crosslink Formation and Reversal with DNA Abasic Sites (2022-06-27)Department: BiochemistryApuirinic/apyrimidinic (AP, or abasic) sites in DNA are one of the most common forms of DNA damage. AP sites are reactive and form crosslinks to both proteins and DNA, are prone to strand breakage, and inhibit DNA replication ...
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(2019-02-12)Department: Chemical and Physical BiologyReplication of our genes requires unwinding of DNA and generating the new complementary strands for both leading and lagging parental strands. The DNA polymerases that generate the complementary strands require a short ...
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(2018-06-26)Department: Biological SciencesDuring DNA replication, a moving replication fork can encounter various sources of replication stress that can lead the moving fork to stall. Organisms have developed various DNA damage response pathways that recruit and ...
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(2011-02-17)Department: Chemical and Physical BiologyAlkylating agents covalently modify DNA bases to generate a chemically diverse set of lesions including cytotoxic N3-methyladenine (3mA) bases and mutagenic 1,N6-ethenoadenine (εA) and N7-methylguanine (7mG). To maintain ...