Browsing Electronic Theses and Dissertations by Subject "C. elegans"
Now showing items 1-11 of 11
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(2009-12-01)Department: PharmacologyPHARMACOLOGY Ca2+-SELECTIVE TRPM CHANNELS REGULATE IP3-DEPENDENT Ca2+ OSCILLATIONS IN THE C. ELEGANS INTESTINE Juan Xing Dissertation under the direction of Professor Kevin Strange Posterior body wall muscle contraction ...
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(2012-04-26)Department: PharmacologyProteostasis is maintained by a complex network of genes and processes which includes core synthesis and degradation machineries as well as chemical and protein chaperones. Much of what is known about the function and ...
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(2017-11-16)Department: NeuroscienceNeurons are specialized cells that communicate through electrochemical signals: a neuron receives input through dendrites and sends information through a single axon. The receptive field for each neuron is defined by sister ...
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(2010-08-17)Department: Interdisciplinary Studies: Molecular NeuropharmacologyThe monoamine neurotransmitter serotonin (5-HT) is an essential component of vertebrate cognitive function and the autonomous nervous system, regulating body temperature, sleep, appetite, and mood. Abnormal 5-HT signaling ...
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(2007-07-30)Department: NeuroscienceIn order to form synaptic connections, an individual neuron needs to coordinate the activities of a large number of proteins. The neuron can modulate the activity of these proteins in a variety of ways. For instance, ...
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Gene-Environment Interactions Between Manganese Toxicity and Early-Onset Parkinson's Disease Genes (2015-03-26)Department: NeuroscienceParkinson’s disease (PD) is a neurodegenerative, motor disorder that is characterized by selective dopaminergic cell loss in the substantia nigra pars compacta. About 10-20% of PD cases have genetic causes; nonetheless, ...
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(2013-07-11)Department: Cell and Developmental BiologyNeurodegenerative diseases are characterized by inappropriate death of distinct neuronal populations. Although symptoms vary, these diseases share pathogenic features such as age-dependent onset and progressive death of ...
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(2012-08-06)Department: Cell and Developmental BiologyNeural function depends on the creation of synapses between specific neurons. Across species, transcription factor codes regulate the precise connectivity between neurons. In the C. elegans motor circuit, these critical ...
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(2017-02-09)Department: NeuroscienceSynaptic circuits are dynamically refined during development as synapses are either stabilized or eliminated. This process requires both neuronal activity and genetic programming; however, the molecules that mediate this ...
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(2018-04-04)Department: NeuroscienceGlutamate (Glu) signaling plays a critical role in regulating neural excitability, thus supporting many behaviors. Perturbed Glu homeostasis in the brain is implicated in multiple psychiatric and neurodegenerative disorders ...
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(2016-06-09)Department: NeuroscienceDopamine is a critical neurotransmitter used across phylogeny to regulate many aspects of behavior. Synaptic control of dopamine signaling is vital for normal nervous system function in humans, and dysregulation of this ...