Browsing Electronic Theses and Dissertations by Department "Molecular Physiology & Biophysics"
Now showing items 1-12 of 12
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(2023-11-21)Department: Molecular Physiology & BiophysicsPancreatic islet insulin secretion is impaired during diabetes pathogenesis, due in part to disruption of β-cell Ca2+ handling. TALK-1 K+ channels are key regulators of ꞵ-cell electrical excitability, Ca2+ entry, and ...
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(2021-08-13)Department: Molecular Physiology & BiophysicsFunctional seizures (FS), paroxysmal episodes that present like epileptic seizures but display no aberrant brain electrical patterns, are understudied. Patients have few treatment modalities and a high rate of comorbidities. Our ...
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(2023-08-15)Department: Molecular Physiology & BiophysicsCCN2 is a matricellular protein that stimulates beta-cell mass expansion during situations of sub-optimal beta-cell mass such as during embryogenesis, after beta-cell ablation, and during pregnancy. It was hypothesized ...
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(2020-03-28)Department: Molecular Physiology & BiophysicsG6PC2 encodes a glucose-6-phosphatase catalytic subunit that is highly expressed in pancreatic islet beta cells. Genome wide association studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the G6PC2 ...
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(2023-08-14)Department: Molecular Physiology & BiophysicsThis thesis identifies the molecular and physiological targets downstream of glucagon-like peptide-1 receptor (GLP-1R) activation that promote the weight-lowering effect of GLP-1R agonists. The first project builds on ...
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(2021-06-14)Department: Molecular Physiology & BiophysicsThe two-pore domain K+ channel, TALK-1 modulates pancreatic β- and δ-cell Ca2+ ([Ca2+]c) entry and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER) handling thereby impacting hormone secretion and glucose tolerance. To investigate ...
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(2023-04-18)Department: Molecular Physiology & BiophysicsHypertension is a major risk factor for heart failure with preserved ejection fraction, and emerging evidence implicates inflammation as integral to its pathogenesis. Clinical samples from patients admitted with heart ...
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(2023-03-07)Department: Molecular Physiology & BiophysicsPancreatic islets perform homeostatic functions thru complex cell-to-cell communication systems that rely on sensing activity from nearby and distant cells. Diabetes mellitus can result from the perturbation of these ...
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(2021-06-03)Department: Molecular Physiology & BiophysicsPancreatic islets are central in the control of blood glucose and their dysfunction is a hallmark of diabetes. Incomplete knowledge of islet biology currently prevents diagnostic and therapeutic approaches based on molecular ...
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(2020-03-30)Department: Molecular Physiology & BiophysicsPrecise regulation of neuronal gene transcription is essential for normal brain function. For instance, neuronal depolarization leads to phosphorylation of the nuclear transcription factor CREB (pCREB), a critical transcription ...
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(2023-11-09)Department: Molecular Physiology & BiophysicsAntisense long non-coding RNAs (antisense lncRNAs) are ubiquitous in the human genome and important for many diseases and biological functions. Despite their importance, the mechanisms by which they exert their function ...
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(2022-06-14)Department: Molecular Physiology & BiophysicsNearly half of adults in the United States report having tried to lose weight in the past year, yet approximately 70% of adults are considered overweight. Recent literature supports the notion that weight regain is common ...