Now showing items 1-13 of 13

    • Meyer, Christian Thomas; 0000-0002-8719-6522 (2020-03-10)
      Department: Chemical & Physical Biology
      Two goals motivate treating diseases with drug combinations: reduce off-target toxicity by minimizing dose (synergistic potency), and improve outcomes by escalating effect (synergistic efficacy). Surprisingly, current drug ...
    • Oleskie, Austin Nicholes; 0000-0002-0622-5038 (2020-11-17)
      Department: Chemical & Physical Biology
      Lung cancer remains the leading cause of all cancer-associated mortalities within the United States. A contributing factor to the high mortality rate is heterogeneous patient response to cancer treatment. This work ...
    • Morris, Andrew Kennedy; 0000-0002-4873-659X (2020-05-19)
      Department: Chemical & Physical Biology
      The nucleoprotein (NP) of the influenza A virus forms the structural packaging factor for the viral genome by its binding to viral RNA as part of the viral ribonucleoprotein. It had been previously shown that replication ...
    • Sauer, Marion Frances; 0000-0002-8010-1279 (2020-06-16)
      Department: Chemical & Physical Biology
      Bioinformatic and epitope mapping approaches have been successful, but are reactive, in determining the mutation preferences and commonly targeted B-cell epitopes of viral fusion proteins. The primary motivation of this ...
    • Setliff, Marion; 0000-0003-4726-6132 (2020-01-21)
      Department: Chemical & Physical Biology
      Pathogen-specific human B cells represent a rich source of antibodies that have been selected for by the process of affinity maturation. In the last few decades, a number of approaches have been developed for the identification ...
    • Venkat, Rohit; 0000-0002-8029-9350 (2020-11-18)
      Department: Chemical & Physical Biology
      For over 30 years, an HIV-1 vaccine has remained elusive due to the high mutability and tremendous levels of genetic diversity exhibited by the virus. Current research efforts have focused on understanding B cell-encoded ...
    • Salay, Lauren Elizabeth; 0000-0001-8513-1891 (2020-11-20)
      Department: Chemical & Physical Biology
      Faithful duplication of DNA lies at the center of DNA replication, defects in which can lead to cancer and other diseases of genomic instability. Generating copies of the two stands of the DNA duplex begins with synthesis ...
    • Pino, James; 0000-0001-9882-6748 (2020-07-13)
      Department: Chemical & Physical Biology
      Predicting how cells respond to drugs is a core concept in systems biology modeling. Current available methods for these signaling analyses can be broadly be classified into two categories: local “bottoms-up” and global ...
    • Pridmore, Michael; 0000-0002-9879-7147 (2020-06-12)
      Department: Chemical & Physical Biology
      The overall goal of this dissertation is to develop and evaluate magnetic resonance imaging (MRI) methods to characterize peripheral nerve microstructure and pathologies in vivo in humans. More specifically, we assessed ...
    • Chacón Simon, Selena; 0000-0002-3960-8609 (2020-04-01)
      Department: Chemical & Physical Biology
      Multiple cellular processes, including cell growth, the cell cycle, metabolism, differentiation, transformation, and apoptosis are regulated by MYC proteins. The frequent deregulation of MYC and its elevated expression via ...
    • JAGESSAR, KEVIN Lindsay; 0000-0003-1475-2513 (2020-04-03)
      Department: Chemical & Physical Biology
      The multidrug and toxic compound extrusion (MATE) transporters are a ubiquitous family of efflux pumps that couples efflux of structurally and chemically diverse molecules to an inwardly-directed Na+ or H+ electrochemical ...
    • Thiemicke, Alexander; 0000-0002-9822-1017 (2020-10-28)
      Department: Chemical & Physical Biology
      Exposure of cells to diverse types of stressful environments differentially regulates cell fate. Although many types of stresses causing this differential regulation are known, it is unknown how changes over time of the ...
    • Perreault, Andrea Anne; 0000-0003-0531-524X (2020-03-20)
      Department: Chemical & Physical Biology
      The hormone erythropoietin (Epo) is required for erythropoiesis, yet its molecular mechanism of action remains poorly understood. To investigate how Epo modulates the erythroid genome, I performed epigenetic profiling using ...